While each volume of Immunological Reviews is devoted to a single topic of immunological resarch, collectively their aim is to provide a broad and continously updated survey of advances in basic immunology and their clinical applications. Selected topics may represent fields in which knowledge or understanding are expanding, areas in which previously seperated lines of investigation are being synthesized or subjects in which previously held view are challenged by more recent findings. Authors invited to contribute to each volume of Immunological Reviews are chosen by the Editorial Board. The tradition of Immunological Reviews is for each author (or group of authors) to focus on reviewing their own contributions and give a synthesis of their research and views. As a group the articles in each volume aim to provide comprehensive coverage of the topic.