Home > Books > Critical Pathways to Success in CNS Drug Development
Critical Pathways to Success in CNS Drug Development
View PDF

Critical Pathways to Success in CNS Drug Development

Publication Year: 2010
Edition: 1st
Authors/Editor: Cutler, Neal R; Sramek, John J.; Murphy, Michael F; Riordan, Henry; Biek, Peter; and Carta, Angelico
Publisher: Wiley
ISBN: 978-1-444-33064-9
  • Description
  • Details
  • Collections

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials

The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials.

The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future.

Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed.

Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

  • Platform:
    Ovid
  • Publisher: Wiley
  • Product Type: Book
  • Author/Editor: Cutler, Neal R; Sramek, John J.; Murphy, Michael F; Riordan, Henry; Biek, Peter; and Carta, Angelico
  • ISBN: 978-1-444-33064-9
  • Specialty:
    Pharmacology
  • Language: English
  • Edition: 1st
  • Pages: 272
  • Illustrations: 0
  • Year: 2010

Critical Pathways to Success in CNS Drug Development is included in the following Collections:

Free Instant Access
This Month

JOTM
CAB Abstracts Covering applied life sciences, CAB Abstracts gives researchers instant access to over 8.4 million records from 1973 onwards, with over 360,000 abstracts added each year.
JOTM
Maternity and Infant Care A key information resource used by maternity health care professionals and student midwives worldwide to support their research, practice, and study requirements.
JOTM
Academic Medicine The journal serves as an international forum to address the major challenges facing the academic medicine community as it strives to carry out its missions in the public interest.
JOTM
Canadian Journal of Addiction The journal provides a forum for presentation of evidence-based, peer-reviewed clinical information and scientific materials to clinicians working in the field of Addiction Medicine.

Noteworthy

Doody's Featured Books
Washington Manual of Pediatrics
This book provides concise rapid-access information to be used while on call, in a critical care setting, in the emergency unit, and in subspecialty outpatient clinics.

Walls Manual of Emergency Airway Management
This book's practical, hands-on approach provides all the concrete guidance you need to effectively respond to any airway emergency.