Guide
Index:
An Introduction to HSDB
The National Library of Medicine
HSDB File Building Process
Chemical Selection
HSDB Record Creation and Maintenance
Peer Review
Data Conventions
HSDB Core Sources
HSDB Field Structure
Fields in HSDB
Limit Fields
Substance Identification
Searching in the Index
Truncation & Wildcards
Combining Searches
Search Examples
Stopwords
Character Set and Indexing
Glossary & Abbreviations
State/Federal Contacts for Drinking Water Standards/Guidelines
Copyright Statement
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In what follows below, many references are made to the general Help Index - please also note that equivalent information can also be found in your SPIRS user manual.
HSDB is a factual, non-bibliographic data bank created and maintained by the National Library of Medicine in the USA, which provides extensive information on identification, manufacturing, use, chemical and physical properties, safety and handling, human and non-human toxicity, pharmacology, environmental fate and exposure, regulations and analytical determinations of chemical substances. HSDB information is organized into chemical records, with records for over 4500 chemical substances. The information in HSDB is completely referenced and fully peer reviewed by the Scientific Review Panel (SRP), a committee of experts drawn from the major scientific disciplines represented within the data bank's scope.
Data are derived from a set of core sources which include standard texts covering these diverse subject areas. HSDB records are also supplemented with information derived from monographs, research reports, current intelligence bulletins and special alert notices. Information concerning US federal regulations is taken from Federal Register Notices and the Code of Federal Regulations series pertaining to the requirements of the Department of Transportation, Occupational Safety and Health Administration, Environmental Protection Agency and the Food and Drug Administration. Data are also taken from the scientific literature.
HSDB is built, reviewed and maintained on the National Library of Medicine's (NLM) Toxicology Data Network (TOXNET).
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If you require further information about HSDB that is not contained in this guide or if you would like to suggest the inclusion of chemical substances not currently in HSDB or if you think there are any omissions or mistakes in the data, then - in the first instance - please contact the HSDB Database Manager at:-
The Department of Health & Human Services,
National Library of Medicine,
Division of Specialized Information Services,
Toxicology and Environmental Health Information Program (TEHIP),
HSDB File Manager,
8600 Rockville Pike,
Bethesda,
MARYLAND 20894,
U.S.A.
Telephone: (301) 496-6531
Fax: (301) 480-3537
Email: toxmail@tox.nlm.nih.gov
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Each year about 100 new chemicals are added to HSDB and another 400 existing chemical records are completely revised and reviewed by the Scientific Review Panel (SRP). In addition, specific record updates are performed on larger numbers of records as, for example, when new editions of sources are published. Such source updates may include the most recent data for Threshold Limit Values (TLV), Department of Transportation Emergency Guidelines (DOT), Immediately Dangerous to Life or Health (IDLH)and the Special Reports (RPTS) fields.
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Chemicals are selected for inclusion into HSDB based on the following factors: chemicals that are produced in large quantities for commercial applications which may have serious health effects or display adverse environmental problems; chemicals that are found on regulatory agency lists such as the Environmental Protection Agency's Acutely Hazardous Substances List, Clean Water and Clean Air Act lists, Drinking Water lists, Federal Insecticide, Rodenticide and Fungicide (FIFRA) lists, Toxic Substances Control Act (TSCA) lists, Suspended, Canceled or Restricted use pesticide lists; Department of Transportation lists, Occupational Safety and Health Administration lists, Food and Drug Administration and the Department of Justice lists.
Chemicals are also selected from non-regulatory federal agencies such as the Agency for Toxic Substances Disease Registry's (ATSDR) list of priority chemicals; the National Institute for Occupational Safety and Health (NIOSH); the National Toxicology Program (NTP) and non-federal groups such as the World Health Organization (WHO), the International Agency for Research on Cancer (IARC) and some trade organizations.
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The processes of HSDB record creation, update and enhancement are generally conducted using a 'text extraction' method. Information is taken from sources 'as is' with little or no modification. This extraction process reduces the potential for misinterpretation of data and allows the user to readily confirm the data in the cited reference source. On the other hand, some information from the Environmental Fate/Exposure Potential Category (ZENE) may be multi-referenced and contain synthesized data; such synthesized data are derived from journal articles, monographs and text books and, in some instances, mathematical models and are not taken verbatim from the source materials.
Before the updating process begins, the entire record is carefully examined. The first step in a complete update cycle is the identification of the most current editions of sources and/or new sources. During the update cycle, the records are examined for missing data. Information is then located using a specific group of standard core texts. Data are also added from special monographs or reports from government or other organizations. Sources of data include the World Health Organization's Criteria Documents, United States Environmental Protection Agency's Health Assessment Documents, Ambient and Drinking Water Criteria Documents, Chemical Hazard Information Profile Documents, and texts and monographs published by the National Research Council of Canada, National Academy of Sciences, National Institute of Occupational Safety and Health, the National Toxicology Program, and the Agency for Toxic Substances and Disease Registry. To obtain the most current information, searches on bibliographic files such as TOXLINE, are performed.
Once the HSDB record has been created or revised, independent groups of scientists examine the record for completeness and accuracy of data. A preliminary review is conducted first by a Quality Control group that reads the entire record for format and content and identifies potential issues or questions that may arise during peer review. This process is completed before the records are released to the Scientific Review Panel (SRP) for a comprehensive peer review.
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The Scientific Review Panel (SRP) is an advisory group made up of nationally and internationally recognized experts in areas of toxicology, pharmacology, environmental fate and chemistry, plant sciences, soil sciences, occupational health and industrial hygiene, environmental engineering and hazardous waste disposal. This group of experts reviews and makes recommendations concerning the accuracy of the data presented in HSDB. This group also makes suggestions for data format, presentation and new data sources for HSDB. The SRP meets quarterly and conducts a comprehensive review of approximately 100 records at each meeting.
N.B. Every data statement in this Croner implementation of HSDB is preceded by a symbol representing the status of that data as determined by the SRP. The symbols which display at the beginning of the data statement, are:
* means PEER REVIEWED, the highest review level.
+ means QC REVIEWED, a lower (preliminary) review level.
? means UNREVIEWED (but a review may take place at some in the future).
No indicator at all means that the data statement will never get reviewed. These statements are usually self-evidently not in need of any review, e.g. CAS numbers.
The symbols are not searchable, but they automatically display or print whenever the field in which they appear is displayed or printed.
Following the SRP meeting, the SRP-reviewed records are revised according to the reviewers' comments and instructions. Revisions needed may include verification of data by checking the source, addition of new information as requested by the SRP and, in some instances, deletion or replacement of data.
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To establish a consistent process for building, updating and enhancing HSDB records, NLM has developed data conventions for extracting information from sources that differ widely in format, references, content and degree of scientific review. Some of these conventions are described here.
Information is presented in concise statements, extracted with no modifications from the text. There are two specific conventions used during the data extraction procedures, as follows.
Ellipsis Convention - The ellipsis convention ( ... ) is used to indicate an omission of data during data extraction. For example, extra wording which imparts no significant information may be deleted and this missing text is indicated by an ellipsis.
Disclaimer Convention - The use of disclaimers (/ /) has multiple meanings, depending on the context. Below are three examples to show how disclaimers are used in the data. In these examples, the short Croner Platter field labels are chosen.
1). In this example, information presented in the excerpt is concerned with the environment fate of inorganic lead. The text describes the fate of inorganic lead as a generic class. Since lead dioxide is an inorganic lead compound, this generic data applies to this compound and is thus cited in the record. The data statement ends with a disclaimer to inorganic lead.
AN: 4335 PN: LEAD-DIOXIDE- FATE: *Terrestrial Fate: Lead in soil is relatively immobile and can persist for long periods of time, whether added to the soil as halides, hydroxides, oxides, carbonates or sulfates (from the combustion of automotive fuels or from industrial processes), as lead arsenate, insecticides, or as an impurity in fertilizers or a component of wastewater. /Inorganic lead/
2). In this example, information presented in the excerpt includes the insertion of the chemical name and explanatory text into the data statement. This allows for clarification of vague textual material.
AN: 202 PN: 2,4-D HTOX: *At present /2,4-D as free/ acid itself is not used as a herbicide. /Toxic effects are reported for the exposure to its salts & esters/. The free acid has somewhat higher toxicity than the sodium salt, the amine salts or the esters.
3). In this example, data concerning the molecular weight of the chemical PARAFORMALDEHYDE has a disclaimer statement associated with it, made by the Scientific Review Panel (SRP). The disclaimer indicates that, based on the knowledge of the panel (referenced to it), this compound has a variable molecular weight.
AN: 4070 PN: PARAFORMALDEHYDE- MW: */SRP: Variable polymer/
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HSDB data comes largely from a core set of evaluated literature sources, primarily from reputable handbooks and textbooks, each of which covers some portion of the file's scope. In addition, government documents, technical reports, and, increasingly, primary journal literature are being used to augment this core set of sources.
Literature sources selected for HSDB contain information about potentially hazardous chemicals, including drugs, to which large numbers of the general population, or a specific and significant subpopulation in an industry or geographical region are exposed.
A Source Evaluation Team at NLM looks at a variety of criteria in identifying and finally selecting sources. Sources are sought which are high in quality (peer reviewed or prepared by an expert committee), presented concisely and well-indexed, of relatively broad scope, containing non-proprietary information, and fairly recent.
A complete set of record references is to be found at the end of each record in the Sources of Data (SO) field. Virtually every HSDB statement is accompanied by a reference number (which follows it and is enclosed in square brackets, [ and ]), except for those statements that occur in the Substance Identification (ZID) and Chemical and Physical Properties (ZCPP) categories.
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There are over 180 field labels in this Croner implementation of HSDB and - in as much as possible and desirable - the overall design has been chosen to be as close as possible to the original TOXNET implementation. This number includes CATEGORIES, HEADERS and MESSAGE FIELDS.
The FIELD is the basic data-containing unit. A field may contain one or more "occurrences" or "statements of data".
HEADERS represent the next level of structure. Headers do not themselves contain data but rather group together conceptually related data fields. Not all data fields are organized into headers (they may be contained within a category). Most header codes start with the letter Z and they can be used to search, show, print or download the group of fields simultaneously. Headers contain a subset of the fields in the enclosing category. There are some special header codes, which do not begin with the letter Z, which used to be simple fields. They are the Human Toxicity Excerpts (HTOX), Interactions (INTC), Non-Human Toxicity Excerpts (NTOX) and TSCA Test Submissions (TCAT) headers each of which can contain up to three fields. This new (August 2001) arrangement allows large amounts of data in the original fields to be handled more effectively and efficiently. Retrieval is not affected as these new headers can be used in place of the original simple field labels (labels remain unchanged).
CATEGORIES, at the highest hierarchical level, group together conceptually related headers and/or data fields. Like headers, the categories themselves contain no data. Each category covers a major area of information about chemical substances. Fields are grouped into ten categories, with each category covering a major area of information about chemical substances. All category codes start with the letter Z and they can be used to search, show, print or download the group of fields simultaneously.
MESSAGE FIELDS, linked to categories, are also present in HSDB. Whenever one or more data fields of a particular category is present, the message field will precede the first such field. These fields are all non-searchable and serve to punctuate the data in records which can be very large. They begin with a blank line followed by text indicating what category fields appear beneath it. This text or heading is surrounded by hyphens.
The categories, message fields and headers in HSDB are listed below (headers appear under the category in which they are contained and are indicated with an asterisk); message field labels appear in square brackets with the categories they refer to:
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Records in HSDB are divided into the following fields. Highlighted fields are limit fields. Asterisked (*) fields are non-searchable.
| Label | Field Name | Label | Field Name | |
| ABIO | Abiotic Degradation | NTXV | Non-Human Toxicity Values | |
| ACTN | Mechanism of Action | OCPP | Other Chemical/Physical Properties | |
| ADE | Absorption, Distribution and Excretion | ODOR | Odor | |
| ADI | Acceptable Daily Intakes | ODRT | Odor Threshold | |
| ALAB | Analytic Laboratory Methods | OEVC | Other Environmental Concentrations | |
| AN | HSDB Accession Number | OFHZ | Other Fire Fighting Hazards | |
| ANTR | Antidote and Emergency Treatment | OHAZ | Other Hazardous Reactions | |
| ARTS | Artificial Sources | OMIN | Other Manufacturing Information | |
| ASCH | Associated Chemicals | OOPL | ||
| ASTD | OPRM | |||
| ATMC | OSHA | |||
| ATOL | OWPC | |||
| AUTO | PFAC | |||
| AVDI | PH | |||
| BHL | PHCY | Pharmacology (*) | ||
| BIOC | PN | |||
| BIOD | POLY | |||
| BION | POPL | |||
| BODY | PRIE | U.S. Production/Imports/Exports | ||
| BP | RADL | |||
| CARC | RCRA | |||
| CERC | CERCLA Reportable Quantities | RD | SRP Review Date (*) |
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| CLAB | REAC | |||
| CLUP | Cleanup Methods | REC | ||
| COFO | REFS | |||
| CORR | RELT | |||
| CPAT | RN | CAS Registry Number | ||
| CPP | RPTS | |||
| CTP | RS | |||
| CWA | RTEX | |||
| DCMP | SAFE | |||
| DEN | SAMP | |||
| DISP | SEDS | |||
| DOT | SERI | |||
| DSC | SHIP | |||
| EFFL | SHPN | |||
| ENEX | SO | Sources of Data (*) |
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| ENVS | SOL | |||
| EQUP | SPEC | |||
| ETOX | SSL | |||
| ETXV | SSTD | |||
| EVAP | STCC | STCC Number | ||
| EXPL | STRG | |||
| EXSR | SURF | Surface Tension | ||
| FATE | SY | |||
| FDA | TAST | |||
| FIFR | FIFRA Requirements | TEST | ||
| FIRP | THER | |||
| FLMT | TLV | |||
| FLPT | TOLR | |||
| FOOD | TOXB | |||
| FORM | TOXC | Toxic Combustion Products | ||
| FPOT | TOXS | |||
| HAZN | TSCA | |||
| HAZS | UD | Update Code | ||
| HIST | USE | |||
| HTC | VAP | |||
| HTV | VAPD | |||
| HTXV | Human Toxicity Values | VISC | ||
| ID | Substance Identification (*) | VWS | ||
| IDIO | WARN | |||
| IDLH | WATC | |||
| IMP | WSTD | |||
| KOC | ZHTA | |||
| MAM | ZHTB | |||
| MANF | ZHTC | Human Toxicity Excerpts (continued) | ||
| MEDS | ZHTD | |||
| METB | ZINA | |||
| MF | ZINB | |||
| MFS | ZINC | |||
| MILK | ZIND | |||
| MINF | ZNTA | |||
| MMFG | ZNTB | |||
| MP | ZNTC | |||
| MW | ZNTD | |||
| MXDD | ZTSA | |||
| NATS | Naturally Occurring Sources | ZTSB | ||
| NFPA | NFPA Hazard Classification | ZTSC | ||
| NREC | ZTSD | |||
| NTP |
Categories and headers appear below:
| HTOX | ZMAN | |||
| INTC | ZNF | |||
| NTOX | ZOPL | |||
| TCAT | ZORE | |||
| ZCPP | ZPHC | |||
| ZENC | ZPHM | Pharmacokinetics | ||
| ZENE | ZPOL | |||
| ZENT | ZPRV | |||
| ZENV | Environmental Transformations | ZREF | ||
| ZEXS | ZSAF | |||
| ZFIR | ZTOB | |||
| ZFLA | Flammable Properties | ZTOE | ||
| ZHAZ | ZTOV | Toxicity Values | ||
| ZHUE | ZWAT | |||
| ZID | ZWRN | |||
| ZMAM |
There is also a special subset of fields, Citation (CITN), which consists of the AN, REC, UD, PN, SY, RN, MF, MW and RS fields. Use Citation to display, print, or save only these fields for a set of records.
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| ABIO | Abiotic Degradation alkaline hydrolysis in abio |
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This field contains information regarding the degradation of the chemical by abiotic processes, such as hydrolysis, photodegradation, or other chemical reactions in the environment. |
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| ACTN | Mechanism of Action (inhibit* near photosynthesis) in actn |
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The ACTN field contains information on how an agent produces its (toxic) effect(s). If a drug, then the therapeutic action of the agent will also be described here. |
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| ADE | Absorption, Distribution and Excretion transported near blood in ade |
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This field contains free text information about the route(s) and rate(s) of absorption, distribution and excretion of the substance; its concentration in body fluids and tissues; the site of its accumulation in vivo; and the form of the excretion and the route. |
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| ADI | Acceptable Daily Intakes mg in adi |
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The amount of a chemical that can be taken daily over a lifetime with minimal risk; usually calculated by dividing the highest no-effect dose determined in laboratory tests by a safety factor of 100. The example search given will retrieve those records for which numeric data is available (normally quoted in mg/l or mg/kg). |
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| ALAB |
Analytic Laboratory Methods silica gel tlc in alab |
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Laboratory assay methods, such as tests for purity, workplace and personnel contamination, and for environmental pollutants. Includes both biological and chemical assays and standard methods from EPA and NIOSH. |
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| AN | HSDB Accession Number 35 in an |
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A unique identification number, up to 4 digits, assigned by NLM to each substance for internal control. This is an efficient and unambiguous way to locate the record for a particular substance. To find all other HSDB records related to the substance, click on the accession number(s) in the Related HSDB Records (RELT) field. This field occurs in EVERY record. |
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| ANTR | Antidote and Emergency Treatment (activated charcoal and magnesium sul* cathartic) In antr |
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Free text information on medical treatment for humans and domestic animals with acute or chronic exposure to toxic substances, on the prevention of toxic effects and on emergency medical procedures. |
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| ARTS | Artificial Sources gasoline exhaust in arts |
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The ARTS field contains information concerning sources of pollution from industrial operations, processes or applications, e.g. vaporization losses, stack emissions, overflow run-off. |
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| ASCH | Associated Chemicals aniline hydrochloride in asch |
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This field contains the names (in original, unhyphenated form - see the Prime Name (PN) field) and CAS Registry Numbers (RN) of chemical substances for which there are no HSDB records, but information about which can be found in the HSDB record for the title compound. This field may list chemicals which are salts, hydrate, etc. of the title compound. For example, there are no HSDB records for sodium saccharin or calcium saccharin, but the HSDB record for saccharin (AN #669) does contain information about these salts, and so their names and CAS Registry numbers are found in the ASCH field. The format for this field is chemical name; CAS Registry number, e.g., Sodium Saccharin; 128-44-9. |
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| ASTD | Atmospheric Standards hazardous air pollutant in astd | ||||||||||||||||
The data in this field contain key standards (e.g. allowable concentrations) promulgated under federal air pollution control statutes including the Clean Air Act. The example search given will find all the chemicals in HSDB which have been designated as "hazardous air pollutants" under section 112 of the Clean Air Act. |
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| ATMC | Atmospheric Concentrations ground level in atmc |
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Concentrations of the chemical in the atmosphere, including geographical location of measurement. |
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| ATOL | Allowable Tolerances popcorn in atol |
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The ATOL field contains legal limits for the concentration of the compound on or in specific foods, established under the authority of the Food, Drug, and Cosmetics Act, as amended. Also, the US Environmental Protection Agency provides tolerances for pesticides. |
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| AUTO | Autoignition Temperature | ||||||||||||||||
Minimum temperature to initiate self-sustained combustion independently of an external heating source, such as spark or flame. As the data only contains temperatures, it is not particularly useful to search in and so no search example is given. |
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| AVDI | Average Daily Intake cognitive in st |
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The amount of the chemical consumed by human adults, as determined by multiplying typical concentrations in drinking water, air, and food by average intake factors. See also the Acceptable Daily Intake (ADI), Water Concentrations (WATC), Atmospheric Concentrations (ATMC), Milk Concentrations (MILK) and Food Survey Values (FOOD) fields. As the key information in this field contains a broad range of different types of numeric data, it is not particularly useful to search in and so no search example is given. |
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| BHL | Biological Half-Life (half life or half time) near days in bhl |
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The time required for a living tissue, organ, or organism to eliminate one-half of the exogenous compound that has been introduced into it. |
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| BIOC | Bioconcentration eel* in bioc |
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The tendency of the chemical to concentrate in an organism; usually expressed as the logarithm of the ratio of the concentration of the chemical in an organism. |
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| BIOD | Biodegradation (biodegrad* near (rapid* or quick* or readily or fast)) in biod |
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The BIOD field contains information on the transformation of the chemical by microorganisms in various media (e.g. soil, surface water, sediment, sewage). Includes Biological Oxygen Demand (BOD) data. |
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| BION | Bionecessity anorexia in bion |
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Information on how much of an essential substance, such as a vitamin, is needed and on what happens when there is a deficiency or excess of the substance. |
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| BODY | Body Burdens blood concentrat* in body |
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The BODY field contains numerical concentrations (for human data only) which accumulate and persist in organs and tissues. Includes values for human milk. |
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| BP | Boiling Point anorexia in bion |
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Under standard or stated conditions, this is the temperature at which an enclosed liquid escapes from the surface and the transition to the gaseous phase occurs. In a closed system the liquid and vapor are in equilibrium. The temperatures are given in degrees Centigrade and are sometimes accompanied by a specific pressure value. As the data only contains temperatures, it is not particularly useful to search in and so no search example is given. |
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| CARC | Evidence of Carcinogenicity a1 in carc |
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This field contains summary carcinogenicity ratings and evaluations from IARC (International Agency for Research on Cancer), ACGIH (American Conference of Governmental Industrial Hygienists) and IRIS (EPA's Integrated Risk Information System). The search example given above uses an IARC code which is equivalent to "confirmed human carcinogen". |
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| CERC | CERCLA Reportable Quantities extrememly hazardous |
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Threshold levels for those chemicals which, if released, must be reported under section 103(a) and (b) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). |
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| CLAB | Clinical Laboratory Methods fluorimetr* in clab |
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The CLAB field contains information regarding methods to detect the chemical, or its metabolite, or a reference enzyme activity in body fluids or tissues (e.g., blood or urine). Also conditions of storage or shipment for a biological specimen and its half-life. Note that the truncated search example above will retrieve those records containing words such as "fluorimetry", "fluorimetric" and "fluorimetrically". |
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| CLUP | Cleanup Methods evaporate near safe place in clup |
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Procedures for cleaning up the chemical after a spill or leak. Includes methods for minor accidents such as in a chemical laboratory as well as procedures for large-scale emergencies. |
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| COFO | Color/Form oily liquid in cofo |
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The COFO field contains any identifying aspects in appearance of the substance, and the physical state (solid, liquid or gas) of the substance in question. For example: colorless crystals, blue powder, pink emulsion, etc. |
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| CORR | Corrosivity noncorrosive in corr |
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The property of etching or eating away of non-biological material by chemical action. |
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| CPAT | Consumption Patterns (essence? or perfume?) in cpat |
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The CPAT field contains usage data expressed as percentages of the total production devoted to each use. |
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| CPP | Chemical and Physical Properties (a message field) |
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The CPP field is displayed in records but is not searchable and contains the following text: CHEMICAL AND PHYSICAL PROPERTIES CATEGORY (USE CODE ZCPP). Its purpose is to act as a record section delimiter. The Chemical and Physical Properties category (ZCPP) is associated with this message field. |
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| CTP | Critical Temperature and Pressure oily liquid in cofo |
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The pressure of the liquid/vapor at which the "critical" point occurs where temperature and pressure bring the two phases of the substance into one phase. As the data only contains temperatures and pressures, it is not particularly useful to search in and so no search example is given. |
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| CWA | Clean Water Act Requirements toxic pollutant in cwa |
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The Clean Water Act (CWA), as amended in 1987, was designed to restore and maintain the chemical, physical and biological integrity of the nation's waters. It includes provisions for national ambient water quality criteria (used by States in setting water quality standards) and for effluent limitations on priority pollutants, in addition to a variety of other clean water requirements, initiatives and programs. |
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| DCMP | Decomposition phosgene in dcmp |
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The DCMP field contains information about the hazardous breakdown of the chemical with release of much heat and threat of fire/explosion. Example: maleic anhydride can decompose explosively in the presence of strong acids or bases, particularly when hot. |
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| DEN | Density/Specific Gravity | ||||||||||||||||
Density is the ratio of weight to volume of a substance, usually expressed as grams/cc; specific gravity is the ratio of weight to weight of the same volume of a standard substance, usually water. Water weighs 1 gram/cc. Since weights vary with temperature, it is necessary to state both temperatures involved. As the key information given contains numeric data, it is not particularly useful to search in and so no search example is given. |
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| DISP | Disposal Methods pesticide incinerators in disp |
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This field contains conditions and cautions for long-term (permanent) disposal of a chemical; also includes inactivation methods, incineration methods, chemical or biological treatment or air stripping. |
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| DOT | DOT Emergency Guidelines suffocat* in dot |
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The DOT (Department of Transportation) field contains information taken from the Emergency Response Guidebook published by DOT. The guidebook was developed for use by firefighters, police and other emergency personnel. The information is intended to provide guidance primarily during the initial stages of an emergency, such as a spill. |
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| DSC | Dissociation Constants pesticide incinerators in disp |
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The numerical value of the equilibrium between undissociated and dissociated forms of a molecule. A higher value indicates greater dissociation. Sometimes the log (10) values are given instead or in addition. As the information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| EFFL | Effluents Concentrations exhaust gas in effl |
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Concentrations of the chemical in effluent streams (e.g. stack emissions) including the source of the effluent. |
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| ENEX | Environmental Fate/Exposure Potential (a message field) |
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The ENEX field is displayed in records but is not searchable and contains the following text: ENVIRONMENTAL FATE/EXPOSURE POTENTIAL CATEGORY (USE CODE ZENE). Its purpose is to act as a record section delimiter. The Environmental Fate/Exposure Potential category (ZENE) is associated with this message field. |
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| ENVS | Environmental Fate/Exposure Summary contaminated fish near exposure in envs |
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The ENVS field contains the narrative statement for this category, including important sources of release, environmental fate and exposure information. |
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| EQUP | Protective Equipment and Clothing dust mask in equp |
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Includes information on respirators (need for and type), eye protection, clothing/boots/gloves, etc. |
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| ETOX | Ecotoxicity Excerpts mortality in etox bees in etox aquatic species in etox |
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This field contains free text excerpts containing ecotoxicity information for mammals, birds, aquatic species, plants and other terrestial species. Field study and accidental poisoning information can also be found here. Occasionally, toxic and lethal dosages are presented although the Ecotoxicity Values (ETXV) is the main source for this numerical data. |
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| ETXV | Ecotoxicity Values guppy in etxv (((1 adj ppm) or (0.* adj ppm)) in etxv) near lc50 |
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The ETXV field contains toxic and lethal dosages for wildlife studies, in the following order: data name (for aquatic organisms data are expressed as LC50, TLm, EC50, etc.); species; strain, if given; sex and age, if given; route of administration, if given; value or numerical dosage; and toxic effect, if stated. The second search example finds all those LC50 values in HSDB which are less than or equal to 1 ppm (part per million). The adj operator retrieves records with search terms next to each other in a specified order (the search phrase '1 ppm' would retrieve records containing both 1 ppm and ppm/1 hr - the latter hits are undesirable). Note also the use of brackets. If the brackets were not included in the search phrase the search engine would actually search for (1 adj ppm) or ((0.* adj (ppm in etxv)) near lc50) which is entirely different and would yield a different result set because, for example, the 1 adj ppm search is NOT confined to the etxv field but to the whole free text index. |
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| EVAP | Relative Evaporation Rate | ||||||||||||||||
The ratio of the evaporation rate of the substance to that of either butyl acetate or diethyl ether. As the information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| EXPL | Explosive Limits and Potential peroxide? in expl |
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This field contains information about the explosivity of a chemical as well as its upper and lower numerical explosive limits; conditions under which the compound is likely to explode. |
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| EXSR | Exposure Standards and Regulations (a message field) |
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The EXSR field is displayed in records but is not searchable and contains the following text: EXPOSURE STANDARDS AND REGULATIONS CATEGORY (USE CODE ZEXS). Its purpose is to act as a record section delimiter. The Exposure Standards and Regulations category (ZEXS) is associated with this message field. |
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| FATE | Environmental Fate reaction near ozone in fate |
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The important transformation and transport processes which affect the fate of the chemical in soil, water, or atmosphere. See also the Biodegradation (BIOD), Abiotic Degradation (ABIO), Soil Adsorption/Mobility (KOC) and Volatilization from Water/Soil (VWS) fields. |
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| FDA | FDA Requirements prescription drug in fda |
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The FDA field contains key requirements under the Food, Drug, and Cosmetics Act, as amended. |
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| FIFR | FIFRA Requirements bioaccumulation in fifr |
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The FIFR field contains the key requirements under the Federal Insecticide, Fungicide and Rodenticide Act. |
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| FIRP | Fire Fighting Procedures alcohol foam in firp |
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Types of extinguishers to be used, need for special protective clothing, recommendations or warnings on extinguishing methods, etc. That an extinguishing medium is hazardous or ineffective would be noted, especially if its use would increase the fire hazard. |
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| FLMT | Flammable Limits prescription drug in fda |
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Minimum concentration (lower flammable limit or LFL) of vapor below which combustion will not occur even in the presence of an external ignition source and maximum vapor concentration (upper flammable limit or UFL) above which combustion cannot take place. As the key information given contains numeric data, it is not particularly useful to search in and so no search example is given. |
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| FLPT | Flash Point | ||||||||||||||||
Minimum temperature at which the compound forms ignitable mixture with air or oxygen as measured by the open cup (OC) or closed cup (CC) method. As the information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| FOOD | Food Survey Values (soybeans or soya beans) in food |
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The FOOD field contains information regarding residue levels in food consumed by humans, including market basket surveys. |
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| FORM | Formulations/Preparations eye drops in form |
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This field contains information about mixtures in which the compound is a major component. Includes trade names for the formulation, percentage composition and so on. Also likely additives. |
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| FPOT | Fire Potential flammable in fpot |
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This field contains information regarding the potential of the chemical as a fire hazard; conditions under which ignition will occur. Example: diborane ignites spontaneously in moist air. |
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| HAZN | EPA Hazardous Waste Number d009 in hazn |
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A 4 character alphanumeric number (1 alphabetic followed by 3 numerics, e.g. F003) provided under 40 CFR (Code of Federal Regulations), subparts C and D. For each hazardous substance the code specifies compound name, waste source, and/or hazardous characteristic (ignitability, corrosivity, reactivity or toxicity). There may be more than one such code assigned to a chemical. Explanatory text appears after the code. Using this field is an efficient way of narrowing down a search or obtaining records which are related to each other. This field occurs in about 10% of the HSDB records. |
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| HAZS | Hazards Summary death in hazs |
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The HAZS field contains narrative informative statements, summarizing salient points from this Safety and Handling category (ZSAF). See also the Immediately Dangerous to Life or Health (IDLH )and Threshold Limit Values (TLV) fields. |
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| HIST | Prior History of Accidents spil* near ((lake or river) in hist) |
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This field contains the history of prior accidents, spills or other emergencies. |
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| HTC | Heat of Combustion | ||||||||||||||||
The amount of heat released in the oxidation of 1 mole of vapor into liquid at constant temperature and pressure. As the information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| HTV | Heat of Vaporization | ||||||||||||||||
The quantity of heat required to convert a quantity of liquid at a definite temperature to vapor at the same temperature. Usually expressed in calories per gram, but also in BTU/lb or joules/kg. As the information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| HTXV | Human Toxicity Values | ||||||||||||||||
Toxic and lethal dosages for human studies containing the data type name (e.g. LC50, Irritant Dose, etc.) sex and age (if given), route of administration, value or numerical dosage and toxic effect, if stated. As the key information given contains numeric data, it is not particularly useful to search in and so no search example is given. |
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| ID | Substance Identification (a message field) |
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The ID field is displayed in records but is not searchable and contains the following text: SUBSTANCE IDENTIFICATION CATEGORY (USE CODE ZID). Its purpose is to act as a record section delimiter. The Substance Identification category (ZID) is associated with this message field. |
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| IDIO | Drug Idiosyncracies asthma in idio |
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Unexpected reactions associated with the therapeutic administration of drugs. |
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| IDLH | Immediately Dangerous to Life or Health human carc* in idlh |
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The IDLH field contains either information about the maximum exposure level (concentration in ppm or mg/cu m) for 30 minutes without incapacitating symptoms or irreversible health effects or a statement from NIOSH (National Institute of Occupational Safety and Health) indicating that the substance be treated as a potential human carcinogen. |
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| IMP | Impurities phosphorus in imp |
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This field contains data about common impurities or contaminants associated with the chemical, such as kerosene and diesel oil in petroleum distillate. |
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| KOC | Soil Adsorption/Mobility sand in koc |
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The partitioning of a chemical between soil or sediment, usually expressed as K (the concentration of a chemical in soil (ug/g) to that in water (ug/ml)) or as Koc (which is K divided by the organic carbon content of the soil or sediment). |
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| MAM | Monitoring and Analysis Methods (a message field) |
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The MAM field is displayed in records but is not searchable and contains the following text: MONITORING AND ANALYSIS METHODS CATEGORY (USE CODE ZMAM). Its purpose is to act as a record section delimiter. The Monitoring and Analysis Methods category (ZMAM) is associated with this message field. |
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| MANF | Manufacturing/Use Information (a message field) |
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The MANF field is displayed in records but is not searchable and contains the following text: MANUFACTURING/USE INFORMATION CATEGORY (USE CODE ZMAN). Its purpose is to act as a record section delimiter. The Manufacturing/Use Information category (ZMAN) is associated with this message field. |
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| MEDS | Medical Surveillance ((test? or analysis) near blood) in meds |
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Free text information on medical tests and procedures to be used in occupational health monitoring or as follow-up care in poisonings. |
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| METB | Metabolism/Metabolites glucose in metb |
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This field contains free text information on in vivo and in vitro metabolism; includes the metabolic reaction and breakdown products, as well as how the title compound is formed (i.e., synthesized) during the metabolism of another substance. |
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| MF | Molecular Formula c2-h6-0 in mf uvcb in mf |
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The elemental composition of a chemical substance in terms of the number and kinds of atoms contained in its structure. The formula is ordered according to the Hill Convention, which is Carbon first, followed by Hydrogen and then in alphabetic sequence by the remaining atomic symbols for both organic and inorganic substances. Each symbol may be searched separately, or you may hyphenate to search the full formula. The designation UVCB or UNIDENTIFIED indicates that the molecular formula is of unknown or variable composition or that the substance is made up of complex reaction or biological products. Apart from the problem of isomerism, this field is nevertheless useful for at least narrowing down or refining searches. This field is present in over 95% of HSDB records. |
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| MFS | Manufacturers ici in mfs |
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The MFS field contains the names and addresses and - when available - telephone numbers of current US manufacturing plants or facilities. |
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| MILK | Milk Concentrations cow in milk |
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Levels of the chemical found in human and animal milk - qualitative as well as quantitative data. |
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| MINF | Minimum/Potential Fatal Human Dose (extremely or super ) in minf |
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Free text information on the least amount of a substance that is lethal to humans with clarifying information such as route of exposure, sex or age of the individual. Many records include a toxicity rating, the key values of which are given below: 1 - practically nontoxic |
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| MMFG | Methods of Manufacturing esterification in mmfg |
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The MMFG field contains information on the most probable methods in the US to manufacture the chemical substance. General information about the method is given, such as continuous versus batch processes, exothermic vs. endothermic reactions, patent information about methods of manufacturing, and alternate methods of synthesis and manufacture. |
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| MP | Melting Point | ||||||||||||||||
The melting point is the temperature at which the solid state of a pure substance changes to a liquid. The freezing point is the temperature at which a liquid and solid exits in equilibrium. Melting points are usually presented in degrees Centigrade. As the data only contains temperatures, it is not particularly useful to search in and so no search example is given. |
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| MW | Molecular Weight | ||||||||||||||||
The sum of the atomic weights of all the atoms in the molecule. As the information given is floating point numeric data, it is not particularly useful to search in and so no search example is given. |
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| MXDD | Maximum Drug Dose child* in mxdd |
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The MXDD field contains information concerning the maximum daily dose of drugs that can be tolerated by humans without manifestation of toxicity. |
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| NATS | Naturally Occurring Sources marine algae in nats |
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This field contains natural sources of the chemical including, for example, components of the earth's crust, volcanic combustion products, emission of terpene hydrocarbons by trees, etc. |
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| NFPA | NFPA Hazard Classification 4 near flamm* in nfpa |
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The NFPA field contains numeric ratings from 0 (no special hazard) to 4 (extreme hazard), as assigned by the NFPA (National Fire Protection Association) for hazards of health, flammability and reactivity. |
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| NREC | NIOSH Recommendations skin in nrec |
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Safe workplace practices and air concentrations as recommended by NIOSH (National Institute for Occupational Safety and Health) to the Occupational Safety and Health Administration. |
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| NT | Notes non-searchable field |
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This field provides an explanation of how the data have been distributed among various related chemical records. For example, the NT field will describe how information has been distributed among a metal cluster, including the elemental metal record, the generic metal compounds record, and the individual compound-specific records. |
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| NTP | National Toxicology Program Reports tumor* in ntp "not" carcinogenic in ntp |
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Test results reported in this field are derived from studies supported by the National Toxicology Program to characterize and evaluate the carcinogenic potential of selected chemicals in laboratory animals. Note the use of quotation marks around the word not in the second search example. Otherwise, the word will be interpreted as the not operator. |
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| NTXV | Non-Human Toxicity Values ld50 rat dermal in ntxv ld50 mouse oral near2 ((1? adj mg) or (2? adj mg) or (3? adj mg) or (4? adj mg) or (5? adj mg) or (6? adj mg) or (7? adj mg) or (8? adj mg) or (9? adj mg)) |
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Toxic and lethal dosages for animal and other non-human studies containing the data type name (e.g. LC50, Irritant Dose, etc.), species strain (if given), sex and age (if given), route of administration, value or numerical dosage and toxic effect, if stated. The second search example finds LD50 values for mice between 1 and 99 mg/kg for the substance adminstered orally. The adj operator ensures that the search engine finds the terms adjacent to each other and in the order specified. The use of brackets ensures the search engine performs the correct search by executing the sub-searches within the innermost matching brackets first. |
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| OCPP | Other Chemical/Physical Properties latent heat near sublimation in ocpp |
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The OCPP field contains data on chemical and physical properties not present elsewhere in the HSDB database. Examples are conduction, particle size, electrical charge, valence, state, Henry's Law constants and so forth; values for physical or chemical properties already cited in other fields are those at different physical conditions (e.g. vapor pressures, boiling points). Also given are chemical and physical properties for isomers, salts, hydrates or other forms of the compound. |
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| ODOR | Odor medicinal in odor |
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This field contains the property of a substance that affects the sense of smell. It varies greatly in penetration, persistence, pleasantness, etc. "Characteristic" is often used when comparison to a categorical olfactory response is not possible. Examples are odorless, pungent, fruits, etc. |
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| ODRT | Odor Threshold | ||||||||||||||||
This field contains information pertaining to the ability to detect the chemical by smell and can serve as a warning signal, but individual thresholds vary considerably. The collective threshold is the minimum odorous concentration sensed by 50% of a group of healthy individuals. The units used are usually mg (or g)/l (cu m) or ppm (parts per million). As the key information given is largely made up of numeric data, it is not particularly useful to search in and so no search example is given. |
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| OEVC | Other Environmental Concentrations cigarette smoke in oevc |
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The OEVC field contains environmental concentrations of the substance in environments not covered elsewhere in the Environmental Concentrations header (ZENC). See also the Environmental Fate/Exposure Potential category (ZENE). The search above will yield a set of records for which there is information concerning the presence of the substance in cigarette smoke. |
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| OFHZ | Other Fire Fighting Hazards poisonous gas* in ofhz |
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This field contains information about the conditions not covered in other fields making up the Fire Fighting Information header (ZFIR) (see also the Safety and Handling category (ZSAF)) that would significantly increase the hazard of a fire, such as production of dense smoke. |
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| OHAZ | Other Hazardous Reactions non-searchable field |
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The OHAZ field contains information about any remaining hazards not specifically identified in the Hazardous Reactions header (ZHAZ) (see also the Safety and Handling header (ZSAF)), such as the effects of pressure, impact, drying, production of dense smoke, etc. This field currently appears rarely so no search example is given. |
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| OMIN | Other Manufacturing Information remov* near distil* in omin |
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Details on process, small laboratory synthesis, preparations, general patent information and manufacturing trends. |
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| OOPL | Other Occupational Permissible Levels (germany in oopl) and (cl* in mf) |
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The OOPL field contains information regarding recommended permissible levels in workplace air, excluding OSHA standards and NIOSH recommendations. Maximum Allowable Concentrations (MACs) and Threshold Limit Values over a Time-Weighted average (TWA-TLV) from other countries are included here. See also related data in the Theshold Limit Values field (TLV). |
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| OPRM | Other Preventive Measures spill* in oprm |
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Includes information on preventive agents, washing and decontamination procedures, ventilation control, administrative and engineering controls, personnel warnings, etc. |
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| OSHA | OSHA Standards non-searchable field |
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Standards promulgated by OSHA (Occupational Safety and Health Administration), which establishes permissible levels and safe work practices and processes for approximately 500 substances. See also the NIOSH Recommendations (NREC) and Other Occupational Permissible Levels (OOPL) fields. As the key information given is largely made up of numeric data, it is not particularly useful to search in and so no search example is given. |
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| OWPC | Octanol/Water Partition Coefficient | ||||||||||||||||
The ratio in which a dissolved substance distributes itself between two immiscible solvents (usually n-octanol and water) at a constant temperature. The Kow is unitless and is expressed as the log. The Kow for Tetrahydrofuran, for example, is log Kow = 0.93. As the key information given is largely made up of numeric data, it is not particularly useful to search in and so no search example is given. |
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| PFAC | Plant/Fish & Seafood/Animal Concentrations grey seal in pfac beans in pfac mussels in pfac plant conc* in pfac fish seafood conc* in pfac animal conc* in pfac |
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The PFAC field contains concentrations of the chemical found in various plants, fish & seafood and animals including geographical location of the measurement. If there is data regarding plants, it will be preceded by a PLANT CONCENTRATIONS: heading. Similarly, if there is data regarding fish & seafood it will be preceded by a FISH/SEAFOOD CONCENTRATIONS: heading. Finally, if there is data regarding animals, it will be preceded by an ANIMAL CONCENTRATIONS: heading. The last three search examples given above show how to find all plant or fish/seafood or animal chemical concentration data in the database. |
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| PH | pH non-searchable field |
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The PH field contains the negative log of the hydrogen ion concentration in moles/liter. The pH ranges from 1 - 14 with pure water at pH 7.0. Lower values than this indicate acidity whilst higher values indicate alkalinity. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| PHCY | Pharmacology (a message field) |
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The PHCY field is displayed in records but is not searchable and contains the following text: PHARMACOLOGY CATEGORY (USE CODE ZPHC). Its purpose is to act as a record section delimiter. The Pharmacology category (ZPHC) is associated with this message field. |
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| PN | Prime Name of Substance aniline in pn benzene- in pn 1234-tetrachlorobenzene- in pn |
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HSDB includes two fields for substance names. This field contains a single, common, generally recognized name of the chemical. The Synonyms (SY) field contains additional chemical, generic, trivial or trade name(s) of the substance. Each of these fields can be searched individually but in general it is best to use the combination Name Fragments header (ZNF) to search both fields SIMULTANEOUSLY because the name you use may not be the HSDB name selected for the record. If it is not possible to allocate a precise chemical name (i.e. if the substance is of unknown or variable composition, or consists of complex reaction products or biological materials (UVCB)), a short phrase appears instead; e.g. "CHLORINATED-PARAFFINS-". This field is always present in HSDB records. In many cases names have been hyphenated. That is to say that all space characters in the name have been changed to hyphens and a terminal hyphen added. Where this occurs and given the way SPIRS works, this means that the whole name appears in the index in hyphenated form together with each individual term making up the name. The hyphenation and terminal hyphen acts as a device to indicate that the term does indeed come from the prime name or synonym field as opposed to other free text fields where the name will not, in general, be hyphenated in this way. There is another important reason for adding a terminal hyphen - to aid focussed retrieval. For example, the search benzene- in pn retrieves only the one record for the substance benzene, while benzene in pn retrieves all records containing the word 'benzene' in the PN field. Similarly, diethyl-ether- in pn retrieves only the single record for diethyl ether, while diethyl ether in pn retrieves any record with those two words adjacent to each other in the PN field. Whilst this device does not always work, it will always reduce the number of irrelevant records retrieved, in some cases dramatically. As a general rule, hyphenation is not attempted in names which contain 'natural breaks' (such as parentheses, curly braces, brackets, slash characters etc.) or characters other than alphanumerics, commas, hyphens or spaces or names which are over 90 characters long. Each word that appears in the PN field is searchable separately. All parts of common and chemical names, including parent, substituents, modifiers, and locants are individually or collectively searchable, as in the above examples. Do NOT include commas, colons, apostrophes, + characters, etc. in your search statement. Also, parentheses, curly and square brackets should be replaced by spaces in searches. Greek characters should first be translated to their equivalent English words before searching. This translation of Greek characters to words takes place throughout the database, not only in this field. See the section on Character Set and Indexing for more information. It is strongly recommended that you employ the technique of lateral searching (see the general Help Index for more information) when searching for long, complex names or parts of names from the records display area or free text index. Apart from saving you keystrokes, the retrieval software will ensure that the phrase is correctly presented to the search engine. For more information on searching from the index, see the index searching section. |
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| POLY | Polymerization (inhibit* or prevent*) in poly |
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The POLY field contains information regarding the self-reaction of some chemicals to form chains of repeating units with release of much heat and threat of fire/explosion. For example, epichlorohydrin can polymerize in the presence of strong acids or bases, particularly when hot. |
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| POPL | Populations At Special Risk children in popl |
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The POPL field contains information about groups at higher risk of injury from exposure than the normal population due to a pre-disposing factor such as pregnancy, chronic disorders, age factors, diet/lifestyle, etc. |
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| PRIE | U.S. Production/Imports/Exports | ||||||||||||||||
This field contains the most current U.S. production/imports/exports figures available. If there is data regarding production, it will be preceded by a U.S. PRODUCTION: heading. Similarly, if there is data regarding imports it will be preceded by a U.S. IMPORTS: heading. Finally, if there is data regarding exports for the chemical, it will be preceded by a U.S. IMPORTS: heading. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| RADL | Radiation Limits and Potential thorium in radl |
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The radioactive properties for a substance, the energy of decay and the half-life associated with a radioactive chemical. |
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| RCRA | RCRA Requirements solid waste in rcra |
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Key requirements of the RCRA (Resource Conservation and Recovery Act) appear in this field. |
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| RD | SRP Review Date non-searchable field |
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This last review date indicates the most recent date on which the record as a whole was peer reviewed by the SRP (Scientific Review Panel). Thus it gives some indication as to the overall currency of the data. Typically text such as 'Reviewed by SRP on 1/31/98' will appear in m(m)/d(d)/yy format. Sometimes only a single digit may appear for the day or month. This field appears in over 50% of HSDB records; records containing a small amount of data don't tend to have this field present. |
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| REAC | Reactivities and Incompatibilities incandesc* in reac |
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Hazardous interactions with other chemicals or contaminants with which the substance might come into contact. |
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| REC | Record Status (a limit field) m in rec n in rec and asbestosis |
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Includes information on preventive agents, washing and decontamination procedures, ventilation control, administrative and engineering controls, personnel warnings, etc. |
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| REFS | Additional References (a message field) |
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The REFS field is displayed in records but is not searchable and contains the following text: ADDITIONAL REFERENCES CATEGORY (USE CODE ZREF). Its purpose is to act as a record section delimiter. The Additional References Category (ZREF) is associated with this message field. |
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| RELT | Related HSDB Records 1726 in relt metabolite in relt |
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The RELT field contains information on other HSDB records which are chemically similar to the substance in question and which may contain additional information of interest to the user. It includes the HSDB accession number (AN) and corresponding name (in unhyphenated form - see the Prime Name (PN) field for further information) for each related substance. To display the record for the related substance click on its accession number in the AN field. SPIRS will then open an additional window and the related record will be displayed. In WebSPIRS - and where multiple linked records exist - use the right mouse button to open multiple windows. In many cases the reason for the relatedness will also be indicated. The keywords used to describe the relatedness are described below:
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| RN | CAS Registry Number 7778-4* in rn 50-00-0 in rn |
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The RN field contains a unique number of up to nine digits assigned by Chemical Abstracts Service to identify a single chemical substance. Consequently, if this number is known, this is an efficient and unambiguous way of searching for a chemical; likewise with the HSDB Accession Number (AN) field. The last single digit after the second hyphen is a check-digit generated from the other remaining digits in the value. The number is always expressed in a hyphenated format with any leading zeroes omitted. When searching in the RN field, include the hyphens; truncation and wildcards can be used as well (see the first search above) as sometimes similar CAS numbers refer to similar chemicals. A few records contain the word UNIDENTIFIED, typically when the molecular formula (MF) cannot be (precisely) determined. This field is present in 99% of all HSDB records. Some other fields in HSDB, such as the Associated Chemicals (ASCH), contain CAS Registry Numbers for related substances. |
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| RPTS | Special Reports who in rpts |
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This field includes government documents such as ITC profiles, EPA CHIP, other special reports such as documents from the National Academy of Sciences and definitive review articles. The search example given will find all the references to (special) World Health Organization literature in HSDB. |
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| RS | Approximate Record Size ('000's Bytes) (a limit field) 100 in rs rs>200 |
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This field occurs in every record and contains an integer which is the approximate record size in thousands of bytes. This is useful for estimating how many pages a full record will print on once the relationship has been determined by a user and the output device page size using the desired font/point size etc. Although it is the last field in a record, it is included in the Citation (CITN) list of fields so that the approximate size of the record can be seen without having all fields displayed. The second search example given above will list those records whose approximate size is over two hundred thousand bytes. |
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| RTEX | Routes of Human Exposure farm* in rtex |
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The RTEX field contains routes for humans to be exposed to the chemical, e.g., ingestion of contaminated drinking water, inhalation of polluted air, etc. It includes typical and maximum exposures from occupational or environmental sources as well as numbers of human exposures, if known. |
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| SAFE | Safety and Handling (a message field) |
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The SAFE field is displayed in records but is not searchable and contains the following text: SAFETY AND HANDLING CATEGORY (USE CODE ZSAF). Its purpose is to act as a record section delimiter. The Safety and Handling category (ZSAF) is associated with this message field. |
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| SAMP | Sampling Procedures kuderna-danish in samp |
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This field contains information regarding sampling procedures or collection methods for environmental media or biota designed for further laboratory testing of chemical concentrations. The phrase used in the search describes a particular piece of apparatus for concentrating certain chemicals after extraction. |
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| SEDS | Sediment/Soil Concentrations everglades in seds |
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The SEDS field contains information about concentrations of the chemical in sediment and soil and includes the geographical location of the measurement. |
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| SERI | Skin, Eye, and Respiratory Irritations burn* in seri |
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Irritant action, e.g., burning, stinging, eye watering, sneezing, coughing, that can be a warning for dangerous concentrations of the chemical vapor. |
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| SHIP | Shipment Methods and Regulations imo or iata in ship |
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The SHIP field contains information concerning shipment and handling regulations including agencies that regulate the shipment of a chemical, the necessary labeling, the proper containers, temperature, etc. for shipment. Sources of information include: U.S. Code of Federal Regulations |
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| SHPN | Shipping Name/Number - DOT/UN/NA/IMO imo 8.0 in shpn un 2215 in shpn |
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The UN (United Nations) Number is a four-figure code used to identify hazardous chemicals and is used for identification of chemicals transported internationally by road, rail, sea and air. In the UK this number is also called the "Substance Identification Number" or "SI Number". The DOT (U.S. Department of Transportation) number, identical to the UN number, identifies the proper shipping name of hazardous wastes under 49 CFR 170. The NA number is for chemicals NOT recognized for international shipment except to and from Canada. The IMO numerical designation is from the International Maritime Dangerous Goods Code of the International Maritime Organization in London. Using any of these numbers is an efficient way of locating either a particular record for a substance or for obtaining a group of related records. This field occurs in about 25% of the HSDB records. |
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| SO | Sources of Data non-searchable field |
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When the bibliographic source for a particular data statement in an HSDB field is available, the complete reference to that source appears in the SO field at the end of the record. There may be several references per data statement. A number in square brackets following the data itself refers to the reference in the SO field. For example, [R2] after a data statement means that the source of the data is cited in the second reference in the SO field. If a particular source is cited more than once within the record, the page number may appear in the data field, e.g. [R3, p. 46]. Each reference starts on a new line. Occasionally, the full source reference information will appear within or at the end of a data statement. Sources for data in the Substance Identification (ZID) category, however, are not included in the Croner HSDB record. The SO field is displayed in records but is not searchable. |
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| SOL | Solubilities | ||||||||||||||||
The extent to which one chemical substance will dissolve in another, expressed as percent weight or volume or as parts per 100 parts of solvent by weight or volume. If temperature is not stated, it is assumed to be standard. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| SPEC | Spectral Properties | ||||||||||||||||
The SPEC field contains those chemical properties which involve the selective absorption of light at a given wavelength by the chemical substance. Various spectrophotometric instruments can be utilized to analyze absorption spectra in infrared (IR), ultraviolet (UV), or visible light. Includes extinction coefficients. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| SSL | Stability/Shelf Life photo-oxidation in ssl |
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Physical conditions like light, heat, pressure or spontaneous chemical reactions - such as oxidation - that affect the stability of the chemical. |
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| SSTD | Soil Standards | ||||||||||||||||
The SSTD field contains information on key standards promulgated under any federal statute regarding permissible levels in soil. As this field currently appears quite rarely, no search example is given. |
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| STCC | STCC Number 187 in stcc |
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The Standard Transportation Commodity Code is a seven digit code and presented as two digits, a space, three digits, a space and finally two digits. The first two digits are usually 49. The spaces between the components permit the individual parts of the code to be retrieved independently. This is an efficient and unambiguous way of locating a particular substance if the field is present in the record (15% of the records in HSDB include this field). |
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| STRG | Storage Conditions (airtight or air-tight) in strg |
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The STRG field contains information about conditions and precautions for storage, including types of containers, temperature, ventilation, etc. |
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| SURF | Surface Tension | ||||||||||||||||
The property existing in the surface film of liquids which tends to contract the volume into a form with the least surface area. This is usually expressed in dynes/cm at a specific temperature. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| SY | Synonyms pesticide near epa in sy pyridine in sy toluene* in sy |
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For all the chemicals in HSDB, several chemical names and numerous trade, generic and trivial names may be applied to describe the chemical in question. In this field, many of these names are identified to aid users on the range of names which have been used to describe each substance. EPA pesticide chemical code numbers appear where known as do foreign language versions of the synonyms, where available. Hyphenation has been applied to synonyms in exactly the same way as for Prime Names (PN). In general, however, it is best to use the combination Name Fragments header (ZNF) to search both fields SIMULTANEOUSLY because the name you use may not be in the list of HSDB synonyms present for the record. Each word that appears in this field is searchable separately. All parts of common and chemical names, including parent, substituents, modifiers, and locants are individually or collectively searchable, as in the above examples. Do NOT include commas, colons, apostrophes, + characters, etc. in your search statement. Also, parentheses, curly and square brackets should be replaced by spaces in searches. Greek characters should first be translated to their equivalent English words before searching. This translation of Greek characters to words takes place throughout the database, not only in this field. See the section on Character Set and Indexing for more information. It is strongly recommended that you employ the technique of lateral searching (see the general Help Index for more information) when searching for long, complex names or parts of names from the records display area or free text index. Apart from saving you keystrokes, the retrieval software will ensure that the phrase is correctly presented to the search engine. For more information on searching from the index, see the index searching section. |
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| TAST | Taste (sugar or honey) in tast |
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This field contains data regarding the flavors of the substance, when tasted (brought into contact with the tongue). The basic tastes are: bitter, sweet, salty, sour, burning, dry and fruity. |
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| TEST | Test Status (pathology (near assessment or study)) in test |
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The TEST field contains information regarding toxicity tests in progress as conducted under the auspices of the National Toxicology Program (NTP). |
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| THER | Therapeutic Uses expectorant in ther |
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The THER field contains information relating to therapeutic uses of drugs in human and veterinary medicine with general dosage information and indications. |
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| TLV | Threshold Limit Values | ||||||||||||||||
This field contains time-weighted average (TLV-TWA) concentration for a normal work day or work week, considered safe for daily exposure. The Short Term Exposure Limit (TLV-STEL) is the maximum concentration for exposures up to 15 min. The Ceiling limit (TLV-C) should never be exceeded. Also included are Biological Exposure Indices (BEIs). These data represent warning levels of biological response to the chemicals or warning levels of the chemical or its metabolic product(s) in tissues, fluids or exhaled air of exposed workers, regardless of whether the chemical was inhaled, ingested or absorbed via skin. Developed by the American Conference of Governmental Industrial Hygienists (ACGIH). As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. See also related data in the Other Occupational Permissible Levels field (OOPL). |
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| TOLR | Drug Tolerance withdrawal in tolr |
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Information about whether humans develop tolerance or whether other organisms acquire resistance to the drug. |
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| TOXB | Toxicity/Biomedical Effects (a message field) |
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The TOXB field is displayed in records but is not searchable and contains the following text: TOXICITY/BIOMEDICAL EFFECTS CATEGORY (USE CODE ZTOB) Its purpose is to act as a record section delimiter. The Toxicity/Biomedical Effects category (ZTOB) is associated with this message field. |
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| TOXC | Toxic Combustion Products hydrogen sulfide in toxc |
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The toxic or irritating gases and fumes released during combustion or by chemicals that vaporize in fire. |
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| TOXS | Toxicity Summary oral admin* in toxs |
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The TOXS field contains the narrative statement for Toxicity/Biomedical effects category (ZTOB). |
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| TSCA | TSCA Requirements neurotox* near rule in tsca |
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This field contains the key requirements under the Toxic Substances Control Act. The search example given above will find all substances for which it is an EPA requirement for manufacturers and processors to conduct testing for neurotoxicity under the Multi-Substances Rule. |
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| UD | Update Code (a limit field) 200104 in ud ud=200110 ud>=200002 ud<200301 ud=200001-200212 |
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This field contains the year and month of the last revision or modification to the record in the format YYYYMM. In the case of new records, it will initially hold the date of introduction into the database. UD is a limit field and to search it you must use the field code as shown above in the example searches. It is also range searchable and so you can use the operators greater than (>), less than (<), greater than or equals (>=) and less than or equals (<=). You can also specify a range as in the last example. Combine a UD search with other retrieval terms to find records that were updated since the last time you searched. |
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| USE | Major Uses explosive in use |
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The major uses of the chemical in the US. Includes major uses and special uses with a high potential for human exposure. |
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| VAP | Vapor Pressure | ||||||||||||||||
The pressure exerted when a solid or liquid is in equilibrium with its own vapor. This is a function of the substance and temperature. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| VAPD | Vapor Density | ||||||||||||||||
The weight of a unit volume of vapor compared to the weight of an equal volume of dry air at the same temperature and pressure. Usually calculated with reference to a value for air = 1. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| VISC | Viscosity incandesc* in reac |
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The resistance of a solid (powder), liquid or gas to uniformly continuous flow. The data normally includes the units (usually CP (Centipoise)) and temperature of measurement. Example: water has a viscosity of 1 CP at 20 deg C. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| VWS | Volatilization From Water/Soil | ||||||||||||||||
This field contains information concerning the transport of a chemical into the atmosphere from water or soil by evaporation. As the key information given is numeric data, it is not particularly useful to search in and so no search example is given. |
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| WARN | Drug Warning peptic ulcer in warn |
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The WARN field contains information regarding warnings associated with the therapeutic administration of the substance as a drug. |
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| WATC | Water Concentrations lake michigan in watc |
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Concentrations of the chemical in water (specifically drinking water, groundwater, surface water, sea water, rain water, snow and ice) including the geographical location of measurement. |
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| WSTD | Water Concentrations ca in wstd alaska in wstd federal in wstd |
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Federal Drinking Water Standards are the enforceable primary regulatory maximum contaminant levels (MCLs). States by law must adopt regulations that are equivalent to or more strict than the federal standard. Federal Drinking Water Guidelines are recommended levels such as lifetime health advisories, secondary maximum contaminant levels (SMCLs) or other guidance. State Drinking Water Standards are enforceable maximum contaminant levels (MCLs) established by state statute or regulation. However, the data here only cites statute MCLs that are different from or in addition to federal MCLs. State Drinking Water Guidelines are levels which are not specified by law or regulation, but rather through policy, procedure or guidance and may or may not be enforceable. If there is data regarding Federal Drinking Water Standards, it will be preceded by a FEDERAL DRINKING WATER STANDARDS: heading. Similarly, if there is data regarding Federal Drinking Water Guidelines it will be preceded by a FEDERAL DRINKING WATER GUIDELINES: heading. Similar remarks apply State Drinking Water Standards and Guidelines. There is a list of contacts who have provided information on both the drinking water standards and guidelines. The first search example given above will retrieve those records which have data on MCLs of the substance in California (CA). A full list of state code abbreviations can be found in the Glossary & Abbreviations section. You can also use the full state name if you wish (second example). The final search example will yield all those records in HSDB with federal water standards/guidelines information. |
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| ZHTA | Human Toxicity Excerpts | ||||||||||||||||
Please refer to the Human Toxicity Excerpts header (HTOX). |
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| ZHTB | Human Toxicity Excerpts (continued) | ||||||||||||||||
Please refer to the Human Toxicity Excerpts header (HTOX). |
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| ZHTC | Human Toxicity Excerpts (continued) | ||||||||||||||||
Please refer to the Human Toxicity Excerpts header (HTOX). |
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| ZHTD | Human Toxicity Excerpts (continued) | ||||||||||||||||
Please refer to the Human Toxicity Excerpts header (HTOX). |
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| ZINA | Interactions | ||||||||||||||||
Please refer to the Interactions header (INTC). |
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| ZINB | Interactions (continued) | ||||||||||||||||
Please refer to the Interactions header (INTC). |
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| ZINC | Interactions (continued) | ||||||||||||||||
Please refer to the Interactions header (INTC). |
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| ZIND | Interactions (continued) | ||||||||||||||||
Please refer to the Interactions header (INTC). |
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| ZNTA | Non-Human Toxicity Excerpts | ||||||||||||||||
Please refer to the Non-Human Toxicity Excerpts header (NTOX). |
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| ZNTB | Non-Human Toxicity Excerpts (continued) | ||||||||||||||||
Please refer to the Non-Human Toxicity Excerpts header (NTOX). |
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| ZNTC | Non-Human Toxicity Excerpts (continued) | ||||||||||||||||
Please refer to the Non-Human Toxicity Excerpts header (NTOX). |
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| ZNTD | Non-Human Toxicity Excerpts (continued) | ||||||||||||||||
Please refer to the Non-Human Toxicity Excerpts header (NTOX). |
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| ZTSA | TSCA Test Submissions | ||||||||||||||||
Please refer to the TSCA Test Submissions header (TCAT). |
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| ZTSB | TSCA Test Submissions (continued) | ||||||||||||||||
Please refer to the TSCA Test Submissions header (TCAT). |
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| ZTSC | TSCA Test Submissions (continued) | ||||||||||||||||
Please refer to the TSCA Test Submissions header (TCAT). |
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| ZTSD | TSCA Test Submissions (continued) | ||||||||||||||||
Please refer to the TSCA Test Submissions header (TCAT). |
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| HTOX | Human Toxicity Excerpts bleeding in htox |
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This is a special header (which contains data from one original source field) but which may be a combination of up to 4 fields which are:- ZHTA Human Toxicity Excerpts This information is presented in this way to cater for those records which contain large amounts of data. Always use the HTOX field label when searching as it will automatically search across the ZHTA, ZHTB, ZHTC and ZHTD as and when they occur. This header contains free text excerpts describing human toxicity, including information on the mutagenicity, carcinogenicity and teratogenicity of the compound. |
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| INTC | Interactions diabetes in intc |
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This is a special header (which contains data from one original source field) but which may be a combination of up to 4 fields which are:- ZINA Interactions This information is presented in this way to cater for those records which contain large amounts of data. Always use the INTC field label when searching as it will automatically search across the ZINA, ZINB, ZINC and ZIND as and when they occur. This header contains free text excerpts describing in vivo interactions of the title compound with exogenous agents (either other chemical substances or radiation) and resultant biological effects. Such interactants may increase or decrease a toxic response. |
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| NTOX | Non-Human Toxicity Excerpts (bee or bees) in ntox no teratogen* in ntox |
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This is a special header (which contains data from one original source field) but which may be a combination of up to 4 fields which are:- ZNTA Non-Human Toxicity Excerpts This information is presented in this way to cater for those records which contain large amounts of data. Always use the NTOX field label when searching as it will automatically search across the ZNTA, ZNTB, ZNTC and ZNTD as and when they occur. This header contains free text excerpts describing animal toxicity, for domestic and laboratory animals; also toxicity studies on plants, bacteria and viruses. Mutagenicity, carcinogenicity, and teratogenicity are included, if known. |
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| TCAT | TSCA Test Submissions subchronic inhalation in tcat |
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This is a special header (which contains data from one original source field) but which may be a combination of up to 4 fields which are:- ZTSA TSCA Test Submissions This information is presented in this way to cater for those records which contain large amounts of data. Always use the TCAT field label when searching as it will automatically search across the ZTSA, ZTSB, ZTSC and ZTSD as and when they occur. This header contains unpublished test results from industry reports submitted to EPA under TSCA (Toxic Substances Control Act). May involve health effects, environmental effects or environmental fate studies. Because the test submissions are unpublished, TCAT data always carries an UNREVIEWED status tag (preceded by a question mark, ?). |
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| ZCPP | Chemical and Physical Properties | ||||||||||||||||
The ZCPP category combines the following fields so that you can search, show, download or print them simultaneously: Color/Form (COFO) |
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| ZENC | Environmental Concentrations | ||||||||||||||||
The ZENC header combines the following fields so that you can search, show, download or print them simultaneously: Water Concentrations (WATC) |
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| ZENE | Environmental Fate/Exposure Potential | ||||||||||||||||
The ZENE category combines the following fields so that you can search, show, download or print them simultaneously: Environmental Fate/Exposure Summary (ENVS) |
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| ZENT | Environmental Transport | ||||||||||||||||
The ZENT header combines the following fields so that you can search, show, download or print them simultaneously: Bioconcentration (BIOC) |
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| ZENV | Environmental Transformations | ||||||||||||||||
The ZENV header combines the following fields so that you can search, show, download or print them simultaneously: Biodegradation (BIOD) |
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| ZEXS | Exposure Standards and Regulations | ||||||||||||||||
The ZEXS category combines the following fields so that you can search, show, download or print them simultaneously: Immediately Dangerous to Life or Health (IDLH) |
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| ZFIR | Fire Fighting Information | ||||||||||||||||
The ZFIR header combines the following fields so that you can search, show, download or print them simultaneously: Fire Fighting Procedures (FIRP) |
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| ZFLA | Flammable Properties | ||||||||||||||||
The ZFLA header combines the following fields so that you can search, show, download or print them simultaneously: Fire Potential (FPOT) |
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| ZHAZ | Hazardous Reactions | ||||||||||||||||
The ZHAZ header combines the following fields so that you can search, show, download or print them simultaneously: Reactivities and Incompatibilities (REAC) |
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| ZHUE | Human Exposure | ||||||||||||||||
The ZHUE header combines the following fields so that you can search, show, download or print them simultaneously: Probable Routes of Human Exposure (RTEX) |
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| ZID | Substance Identification | ||||||||||||||||
The ZID category combines the following fields so that you can search, show, download or print them simultaneously: Prime Name of Substance (PN) |
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| ZMAM | Monitoring and Analysis Methods | ||||||||||||||||
The ZMAM category combines the following fields so that you can search, show, download or print them simultaneously: Sampling Procedures (SAMP) |
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| ZMAN | Manufacturing/Use Information | ||||||||||||||||
The ZMAN category combines the following fields so that you can search, show, download or print them simultaneously: Methods of Manufacturing (MMFG) |
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| ZTSD | TSCA Test Submissions (continued) | ||||||||||||||||
The ZNF header combines the following fields so that you can search, show, download or print them simultaneously: You should use Prime Name of Substance (PN) You should use this field to search for names unless you are suare the name you are using is in either the PN or SY fields. |
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| ZNF | Name Fragments | ||||||||||||||||
The ZNF header combines the following fields so that you can search, show, download or print them simultaneously: You should use Prime Name of Substance (PN) You should use this field to search for names unless you are suare the name you are using is in either the PN or SY fields. |
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| ZOPL | Occupational Permissible Levels | ||||||||||||||||
The ZOPL header combines the following fields so that you can search, show, download or print them simultaneously: OSHA Standards (OSHA) |
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| ZORE | Other Standards and Regulations | ||||||||||||||||
The ZORE header combines the following fields so that you can search, show, download or print them simultaneously: Atmospheric Standards (ASTD) |
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| ZPHC | Pharmacology | ||||||||||||||||
The ZPHC category combines the following fields so that you can search, show, download or print them simultaneously: Minimum/Potential Fatal Human Dose (MINF) |
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| ZPHM | Pharmacokinetics | ||||||||||||||||
The ZPHM header combines the following fields so that you can search, show, download or print them simultaneously: Absorption, Distribution and Excretion (ADE) |
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| ZPOL | Pollution Sources | ||||||||||||||||
The ZPOL header combines the following fields so that you can search, show, download or print them simultaneously: Naturally Occurring Sources (NATS) |
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| ZPRV | Preventive Measures | ||||||||||||||||
The ZPRV header combines the following fields so that you can search, show, download or print them simultaneously: Protective Equipment and Clothing (EQUP) |
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| ZREF | Additional References | ||||||||||||||||
The ZREF category combines the following fields so that you can search, show, download or print them simultaneously: Special Reports (RPTS) |
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| ZSAF | Safety and Handling | ||||||||||||||||
The ZSAF category combines the following fields so that you can search, show, download or print them simultaneously: Hazards Summary (HAZS) |
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| ZTOB | Toxicity/Biomedical Effects | ||||||||||||||||
The ZTOB category combines the following fields so that you can search, show, download or print them simultaneously: Toxicity Summary (TOXS) |
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| ZTOE | Toxicity Excerpts | ||||||||||||||||
The ZTOE header combines the following fields so that you can search, show, download or print them simultaneously: Human Toxicity Excerpts (HTOX) |
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| ZTOV | Toxicity Values | ||||||||||||||||
The ZTOV header combines the following fields so that you can search, show, download or print them simultaneously: Human Toxicity Values (HTXV) |
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| ZWAT | Water Standards and Guidelines | ||||||||||||||||
The ZWAT header combines the following fields so that you can search, show, download or print them simultaneously: Federal/State Drinking Water Standards/Guidelines (WSTD) |
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| ZWRN | Warning Properties | ||||||||||||||||
The ZWRN header combines the following fields so that you can search, show, download or print them simultaneously: Odor Threshold (ODRT) |
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| CITN | Citation | ||||||||||||||||
The Citation is a special subset of fields consisting of the following: HSDB Accession Number (AN) The Citation serves as an easy way to display, print or download only these fields for a set of records and is included for unique record identification purposes. For information about downloading or printing data, please refer to the general Help Index. |
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Go: Guide Index or Back
The limit fields listed below are specially indexed fields that usually have relatively few possible values. They allow you to limit your searches to records of a particular characteristic, such as an update code.
Update Code (UD)
Approximate Record Size ('000's Bytes) (RS)
Record Status (REC)
You can search these fields with in or =. For example, to retrieve records updated in June 1998, type:
199806 in ud or ud=199806
Similarly, to obtain the new records in the latest update type:
n in rec or rec=n
| Symbol | Operation Performed |
< |
less than |
> |
greater than |
<= |
less than or equal to |
>= |
greater than or equal to |
- |
within a range |
For example the search ud=199701-199712 will retrieve all the records in HSDB that were updated in 1997.
Go: Guide Index or Back
Often the purpose of an HSDB search is to retrieve the single record for a particular chemical substance. The Substance Identification (ZID) data category enables you to retrieve substance records via several access points, including numbers, names, and composition and/or structure.
Using any of the various numbers assigned to a substance is a simple, efficient and precise way of retrieving the substance record. The HSDB Accession Number (AN), if known, is the most efficient way to retrieve a particular record. You can also use the CAS Registry Number (RN) or EPA Hazardous Waste Number (HAZN).
Go: Guide Index or Back
The SPIRS Index function allows you to look up, select, and search for variations of a term. Use the index if you are uncertain of the spelling of a particular term. The index is particularly useful for finding a chemical substance name (ZNF).
For example, to locate information on zirconium and its compounds, look up zirconium in the Index. A segment of the index beginning with this name will be listed; you will see various compounds of zirconium (names with a terminal hyphen will be from either the Prime Name (PN) or Synonyms (SY) fields) as well as other potentially useful terms such as zirconium-induced and zirconium-95.
Thus the index function is useful in potentially narrowing your search, suggesting other related terms and as a check on spelling and will always result in a non-zero hit list.
Refer to the general Help Index for more information on using the index function in SPIRS.
Go: Guide Index or Back
You can use the truncation symbol (*) as a substitute for any string of zero or more characters in your search term. For example, the search migrat* retrieves any record containing "migrated", "migration", "migratory", "migratory-species", etc.
You can use the wildcard symbol (?) as a substitute for one character or none. This can be useful for narrowing down searches, especially if truncation was initially used. For example, the search oxidi?e? retrieves records containing "oxidise", "oxidize", "oxidiser", "oxidizer", "oxidises", "oxidizes", "oxidised" and "oxidized" BUT NOT "oxidation", "oxidating", "oxidizing", etc.
The truncation and wildcard symbols can be used anywhere in your search term, except as the first character.
Go: Guide Index or Back
Beginning a search request with an operator (and, not, or, with, near, or in) automatically combines that request with the previous one.
For instance, if the search you just completed is poison*, searching for near toxic will give you the same results as if you search for poison* near toxic. Similarly, the search silver followed by the search in znf is the same as silver in znf.
Go: Guide Index or Back
The following examples demonstrate how to search HSDB. These examples are not exhaustive, but do illustrate several search techniques. It is important to note that, although all examples are given in lowercase, SPIRS is not case-sensitive; whether your search terms are entered in upper- or lower-case, the same records will be retrieved.
You should also look at the individual examples given for the searchable fields in the field descriptions.
Example 1: Is there any LD50 oral mouse data in new records in this update ? Answer: n in rec and ld50 oral mouse Use the Record Status field (REC) to find the new records for this update and then use the 'and' operator with the phrase 'ld50 oral mouse'. Example 2: How can I find out if the chemical I am interested in exists in the HSDB database ? Answer: Use a field which briefly (via a code or number) uniquely identifies the substance and which appears in every or most records. HSDB contains several such fields which are (best to worst - from an occurrence/retrieval point of view): HSDB Accession Number (AN) CAS Registry Number (RN) Molecular Formula (MF) Shipping Name/Number - DOT/UN/NA/IMO (SHPN) STCC Number (STCC) EPA Hazardous Waste Number (HAZN) If you don't know any of these numbers or codes you should search using the Prime Name or Synonyms fields via Name Fragments header. Example 3: Is there any LD50 information for substances containing barium ? Answer: (ba in mf) or (barium in znf) and ld50 Note that the Molecular Formula field may not be present in every record or Ba may not be the first element in the molecular formula and so an extra search is conducted on the Name Fragments header (ZNF). Note also that the search on LD50 is NOT restricted to any single field as it can occur in several fields. There is no need for an extra set of brackets around the first two intermediate search phrases as the intermediate search involving the "or" operator will be performed BEFORE the final search with the "and" operator. Example 4: What substances in HSDB are classified as extremely flammable by DOT which are likely or definite carcinogens ? Answer: (extremely flammable in dot) and ((group 1? or group 2?) in carc) Note the use of the brackets to ensure the search is performed by the search engine as expected. Note the use of the wildcard as IARC classifications can be made up of either 1 or 2 characters. Example 5: What morphine-type drugs are represented in HSDB ? Answer: morphine in znf No hyphen is used so that ALL records which contain the word morphine as either a prime name or a synonym can be found. The hitlist will include the records for Codeine and Heroin. Example 6: What solvents are suspected of causing brain cancer in humans ? Answer: solvent* in use and (brain near cancer?) in htox Brackets are required here otherwise the last part of the search would be interpreted by the search engine as (and (brain near (cancer in htox)) which may well give different and incorrect results. The near operator is used to constrain the terms "brain" and "cancer?" to be in the same sentence. Example 7: What sulfate-containing records have been updated since 2002 ? Answer: (ud>=200201) and ((sulphate or sulfate) in znf) 200201 is the update code for January 2002. Note the two spelling variants of the word "sulphate" which ensures that records that may be relevant will not accidentally be omitted. Example 8: What chemicals have been implicated in causing hemangiosarcomas ? Answer: hemangiosarcoma* As the main search term in question is very specific, it is sufficient to use it alone without reference to the toxicity excerpts fields (HTOX, NTOX and ETOX). Example 9: Is there any information in HSDB about the effects of lead (compounds) in canned milk ? Answer: lead in znf and canned in milk Note the use of the specific Milk Concentrations field (MILK).
Go: Guide Index or Back
Words of little intrinsic meaning that appear too frequently to be useful in searching text are known as "stopwords". You cannot search for the following stopwords by themselves, but you can include them within phrases:
about |
an |
and |
are |
been |
but |
by |
do |
for |
from |
has |
have |
if |
in |
into |
is |
it |
its |
of |
on |
or |
than |
that |
the |
their |
these |
they |
this |
those |
to |
was |
were |
what |
when |
where |
which |
while |
will |
with |
|
Go: Guide Index or Back
The character set used for indexing and display of HSDB data is ASCII. There are no foreign or accented characters in the data, save for Greek characters which are translated to their English word equivalents (alpha, beta, ALPHA, BETA and so on).
Note also that only the characters A-Z (the case of the character is ignored), 0-9, the hyphen, -, and the full-stop (in floating-point data only), "." can be indexed by SPIRS. This means that when you search, you should omit any punctuation or other characters (except "/", "(" and ")" characters which should be replaced by a space) in the search phrase unless it is enclosed within double quotes. This is particularly important for chemical names.
Go: Guide Index or Back
The character set used for indexing and display of HSDB data is ASCII. There are no foreign or accented characters in the data, save for Greek characters which are translated to their English word equivalents (alpha, beta, ALPHA, BETA and so on).
Common abbreviations in HSDB are listed below. Please note that many abbreviations appear in the data in both lower and upper case and the more common form is cited.
% |
percent |
& |
and |
(g) |
gas |
(l) |
liquid |
+ |
plus |
- |
minus |
< |
less than |
= |
equals |
> |
greater than |
@ |
at |
5-HT |
5-hydroxytryptamine |
|
|
A |
Angstrom |
AADI |
adjusted acceptable daily intake |
abs |
abs(olute) |
accum |
accumulate(s, d, ion) |
ACGIH |
American Conference of Governmental Industrial Hygienists |
AChE |
acetylcholinesterase |
ad lib |
ad libitum |
addn(l) |
addition(al) |
ADI |
acceptable daily intake |
ADP |
adenosine 5'-diphosphate administered |
AFNOR |
Association Francaise de Normalization |
ai |
active ingredient |
AIDS |
Acquired Immune-Deficiency Syndrome |
AIHA |
American Industrial Hygiene Association |
AK |
Alaska |
AL |
Alabama |
alc |
alcohol, alcoholic |
am |
before noon |
AMA |
American Medical Association |
AMP |
adenosine 5'-monophosphate |
amp |
ampere |
amt |
amount |
anal |
analysis(es) |
anhyd |
anhydrous |
AOAC |
Association of Official Analytical Chemists |
approx |
approximate(ly) |
aq |
aqueous |
AR |
Arkansas |
ASHP |
Association of Hospital Pharmacists |
assoc |
associate(s, d, ion) |
AST |
aspartate aminotransferase |
ASTM |
American Society for Testing Materials |
atm |
atmosphere(s) |
ATP |
adenosine 5'-triphosphate |
ATSDR |
Agency for Toxic Substances & Disease Registry |
avail |
available, availability |
avg |
average |
AZ |
Arizona |
BAN |
British Approved Name |
BCF |
bioconcentration factor |
BEI |
biological exposure index |
biochem |
biochemical(s) |
biol |
biology, biological |
BMR |
basal metabolic rate |
BOD |
biological oxygen demand |
BOD5 |
biological oxygen demand (5-day test) |
bp |
boiling point |
Bq |
Becquerel |
BrdU |
bromodeoxyuridine |
BSI |
British Standards Institute |
BTU |
British Thermal Unit(s) |
BUN |
blood urea nitrogen |
bw |
body weight |
C |
Centigrade |
C.I./CI |
Color Index |
CA |
California |
ca |
circa, about |
CAG |
Carcinogen Assessment Group |
cal |
calorie(s) |
CAS |
Chemical Abstracts Service |
CAS RN |
Chemical Abstracts Service Registry Number |
CBC |
complete blood count |
CC |
cubic centimeter(s); closed cup |
CDC |
Centers for Disease Control |
CEQ |
Council on Environmental Quality |
CERCLA |
Comprehensive Environmental Response, Compensation and Liability Act |
CFR |
Code of Federal Regulations |
CG |
Coast Guard |
ChE |
cholinesterase |
chem |
chemical(s) |
CHIP |
Chemical Hazard Information Profile |
Ci |
Curie |
CIIT |
Chemical Industries Institute of Toxicology |
cl |
centiliter |
cm |
centimeter(s) |
CMA |
Chemical Manufacturers Association |
cmpd |
compound(s) |
CNS |
central nervous system |
CO |
Colorado |
co |
company |
COC |
Cleveland open cup |
concn |
concentration(s), concentrate(d) |
corp |
corporation(s) |
CP |
Centipoise |
CPK |
creatine phosphokinase |
CRAVE |
Carcinogenic Risk Assessment Verification Endeavor |
CT |
Connecticut |
cu |
cubic |
cu m |
cubic meter |
CVS |
cardiovascular system |
CWA |
Clean Water Act |
DC |
District of Columbia; direct current |
DDE |
2,2-bis(4-chlorophenyl)-1,1-dichloroethylene |
DE |
Delaware |
decomp |
decompose, decomposition |
decr |
decrease |
deg |
degree |
den |
density |
dept |
department |
deriv |
derivative(s) |
detn |
determination(s) |
DHEW |
US Department of Health, Education, and Welfare (now US Department of Health and Human Services) |
DHHS |
US Department of Health and Human Services |
diam |
diameter |
dil |
dilute |
dist |
district(s) |
div |
division(s) |
DMSO |
dimethyl sulfoxide |
DNA |
deoxyribonucleic acid |
DNASE |
deoxyribonuclease |
DO |
dissolved oxygen |
dom |
domestic |
DOT |
Department of Transportation |
doz |
dozen |
dr |
dram(s) |
EC |
effective concentration; European Community |
EC50 |
effective concentration - 50% |
ECD |
electron capture detection/detector |
ECG |
electrocardiogram (graph) |
ed |
edition |
Ed |
editor |
ED |
effective dose |
EDTA |
(ethylenedinitrilo)tetraacetic acid |
EEC |
European Economic Community, now known as the European Community (EC) |
EEG |
electroencephalogram (graph) |
e.g. |
for example |
eg |
for example |
EKG |
electrocardiogram (graph) |
elim |
elimination(s) |
ELISA |
enzyme-linked immunosorbent assay |
emf |
electromotive force |
EMG |
electromyogram (graph) |
EMLD |
estimated/empirical mean lethal dose |
ENU |
N-ethyl-N-nitrosourea |
environ |
environment(al) |
EP |
extraction procedure |
EPA |
Environmental Protection Agency |
EPR |
electron paramagnetic resonance |
equil |
equilibrium |
equiv |
equivalent(s) |
esp |
especially |
ESR |
electron spin resonance |
est |
estimate |
esu |
electrostatic unit |
et al |
and others (authors) |
evap |
evaporate, evaporation |
exam |
examine, examination |
expt |
experiment |
exptl |
experimental, experimentally |
F |
Fahrenheit |
F1 |
first filial generation (in experimental animals) |
FA |
Florida |
FAO |
Food and Agriculture Organisation |
FDA |
Food and Drug Administration |
FIFRA |
Federal Insecticide, Fungicide and Rodenticide Act |
FMN |
flavin mononucleotide |
fp |
freezing point |
FR |
Federal Register |
ft |
foot, feet |
g |
gram(s) |
G-6-PD |
glucose-6-phosphate dehydrogenase |
GA |
Georgia |
gal |
gallon(s) |
GC |
gas chromatography |
GC-MS |
gas chromatography-mass spectrometry |
GI |
gastrointestinal |
GLC |
gas-liquid chromatography |
GPT |
glutamic-pyruvic transaminase |
gr |
grain(s) |
GSH |
reduced glutathione |
ha |
hectare |
haz |
hazardous |
HB/HGB |
haemoglobin |
HCT |
hematocrit |
HGPRT |
hypoxanthine-guanine phosphorisobutyltransferase |
HI |
Hawaii |
HPLC |
high performance liquid chromatography |
Hq |
headquarters |
hr |
hour(s) |
ht |
height |
Hz |
Hertz |
IA |
Iowa |
IARC |
International Agency for Research on Cancer |
IATA |
International Air Transport Association |
IC50 |
inhibitory concentration - 50% |
ICR |
Institute of Cancer Research |
ICRP |
International Commission for Radiological Protection |
ID |
Idaho |
id |
intradermal |
idlh |
immediately dangerous to life or health |
i.e. |
that is |
ie |
that is |
IL |
Illinois |
ILO |
International Labor Organization |
IMO |
International Maritime Organization |
im |
intramuscular |
in |
inch(es) |
IN |
Indiana |
Inc |
incorporated |
incl |
include |
incr |
increase |
indust |
industries, industrial |
inorg |
inorganic |
insol |
insoluble |
int |
intermediate |
intermed |
intermediate |
ip |
intraperitoneal |
IR |
infrared |
IRIS |
Integrated Risk Information System |
IRPTC |
International Register of Potentially Toxic Chemicals |
irradn |
irradiation |
ISO |
International Standards Organisation |
ITC |
Interagency Testing Committee |
IU |
International Unit |
IUPAC |
International Union of Pure and Applied Chemistry |
iv |
intravenous |
J |
Joule |
K |
Kelvin |
Ka |
dissociation constant |
KA |
Kansas |
kcal |
kilocalorie(s) |
kg |
kilogram(s) |
km |
kilometer(s) |
Koc |
soil sorption coefficient |
Kow |
dissociation constant, octanol:water |
KY |
Kentucky |
l |
liter(s) |
LA |
Louisiana |
lab |
laboratory |
lb |
pound(s) |
LC |
liquid chromatography |
LC50 |
lethal concentration - 50% |
LCLO |
lethal concentration, low |
LD |
lethal dose |
LD50 |
lethal dose - 50% |
LDH |
lactic acid dehydrogenase |
LDLO |
lethal dose, low |
LEL |
lower explosive limits |
LFL |
lower flammable limit |
liq |
liquid |
LOAEL |
lowest observed adverse effect level |
Ltd |
limited |
| Go: Guide Index or Back | |
m |
meter(s) |
M |
molar (moles/liter) |
m- |
meta |
MA |
Massachusetts |
MAC |
maximum admissible concentration |
max |
maximum |
MCA |
Manufacturing Chemists Association |
mCi |
millicurie |
MCL |
maximum contaminant level |
MD |
Maryland |
ME |
Maine |
mech |
mechanical(ly) |
mel |
maximum exposure limit |
MESA |
Mining Enforcement and Safety Administration (replaced by MSHA in 1978) |
metab |
metabolism |
mg |
milligram(s) |
MI |
Michigan |
min |
minute(s) |
misc |
miscellaneous |
MITI |
Ministry of International Trade and Industry, Japan |
mixt |
mixture(s) |
ml |
milliliter(s) |
MLD |
minimum lethal dose |
mm |
millimeter(s) |
mM |
millimolar |
MMAD |
mass median aerodynamic diameter |
mmHg |
millimeters mercury |
mmol |
millimole(s) |
MN |
Minnesota; meganewtons |
MO |
Missouri |
mo |
month(s) |
mol |
molecul(e, es, ar); mole |
mon |
month(s) |
mp |
melting point |
mpe |
maximum permissible exposure |
MPPCF |
million particles per cubic foot |
mRNA |
messenger RNA |
MS |
Mississippi; mass spectrophotometry |
MSHA |
Mine Safety and Health Administration |
MT |
Montana |
MTD |
maximum tolerated dose |
mu |
millimicron(s) |
n |
nano; normal (as applied to concentration) |
N |
Newton; normal (as applied to concentration) |
NADH |
nicotinamide-adenine dinucleotide (reduced form) |
NADPH |
nicotinamide-adenine dinucleotide (oxidised form) |
NAS |
National Academy of Sciences |
NC |
North Carolina |
NCI |
National Cancer Institute |
nd |
no data |
ND |
North Dakota |
NE |
Nebraska |
neg |
negative |
NEI |
National Eye Institute |
NESHAP |
National Emission Standards for Hazardous Air Pollutants |
NFPA |
National Fire Protection Association |
ng |
nanogram(s) |
NH |
New Hampshire |
NHLBI |
National Heart, Lung and Blood Institute |
NIDA |
National Institute of Drug Abuse |
NIEHS |
National Institute of Environmental Health Sciences |
NIH |
National Institutes of Health |
NIOSH |
National Institute of Occupational Safety and Health |
NJ |
New Jersey |
NLM |
National Library of Medicine |
nm |
nanometer(s) |
NM |
New Mexico |
nmol |
nanomole |
NMR |
nuclear magnetic resonance |
NOAEL |
no observed adverse effect level |
NOEC |
no observed effect concentration |
NOEL |
no observed effect level |
NOES |
National Occupational Exposure Survey |
NOHS |
National Occupational Hazard Survey |
NOS |
not otherwise specified |
NRC |
National Response Center |
NTA |
nitrilotriacetic acid |
NTIS |
National Technical Information Service |
NTP |
National Toxicology Program |
NV |
Nevada |
NY |
New York |
o- |
ortho |
OC/oc |
open cup |
OECD |
Organisation for Economic Cooperation and Development |
OH |
Ohio |
OHEA |
Office of Health and Environmental Assessment, US EPA |
OK |
Oklahoma |
OPP |
Office of Pesticide Programs, US EPA |
OPTS |
Office of Pesticides and Toxic Substances, US EPA |
OR |
Oregon |
ORD |
Office of Research and Development, US EPA |
org |
organic |
ORM |
Other Regulated Materials(s) (DOT) |
OSHA |
US Occupational Safety and Health Administration |
OSWER |
Office of Solid Waste and Emergency Response, US EPA |
OTS |
Office of Toxic Substances, US EPA. |
OWRS |
Office of Water Regulations and Standards, US EPA. |
oxidn |
oxidation |
oz |
ounce(s) |
P |
Poise |
p- |
para |
PA |
Pennsylvania |
PAH |
polycyclic or polyaromatic or polynuclear aromatic hydrocarbon(s) |
PBPK |
physiologically based pharmacokinetic |
PCB(s) |
polychlorinated biphenyl(s) |
pCi |
picoCurie |
PE |
polyethylene |
PEG |
polyethylene glycol |
PEL |
permissible exposure limit |
pH |
hydrogen ion concentration (negative log) |
phys |
physical |
pKa |
acid dissociation constant (negative log) |
pKb |
base dissociation constant (negative log) |
pm |
afternoon |
PNS |
peripheral nervous system |
po |
per os (by mouth) |
pOH |
hydroxyl ion concentration (negative log) |
pos |
positive |
ppb |
parts per billion |
pph |
parts per hundred |
ppm |
parts per million |
ppt |
precipitate; parts per thousand |
pptn |
precipitation |
PR |
Puerto Rico |
prepd |
prepared |
prepn |
preparation |
psi |
pound force per square inch |
pt |
patient |
PTFE |
polytetrafluoroethylene |
qid |
four times a day |
QSAR |
Quantitative Structure Activity Relationships |
qt |
quart(s) |
qual |
qualitative(ly) |
quant |
quantitative(ly) |
R |
Roentgen(s) |
RAD |
radiation absorbed dose |
RBC |
red blood cells |
RCRA |
Resource Conservation and Recovery Act (US) |
RD50 |
50% decrease in respiratory rate |
redn |
reduction |
ref |
reference |
REL |
recommended exposure limit |
resp |
respiration, respiratory |
RfD |
(Oral) Reference Dose |
RI |
Rhode Island |
RN |
Registry Number (CAS) |
RNA |
ribonucleic acid |
RPAR |
rebuttable presumption against registration |
rpm |
revolutions per minute |
RQ |
reportable quantity |
rRNA |
ribosomal RNA |
RTECS |
Registry of Toxic Effects of Chemical Substances |
SAB |
Science Advisory Board |
SC |
South Carolina; subcutaneous |
sce |
sister chromatid exchange |
SD |
South Dakota |
sec |
second(s) |
sepn |
separation |
SGOT |
serum glutamic-oxaloacetic transaminase |
SGPT |
serum glutamic-pyruvic transaminase |
sigma g |
geometric standard deviation |
SMR |
standard mortality ratio |
sol |
soluble |
soln |
solution |
sp |
species (in taxonomy) |
sp gr |
specific gravity |
sq |
square |
SRC |
Syracuse Research Corporation |
SRP |
Scientific Review Panel |
ST |
Saint |
std |
standard |
STCC |
Standard Transportation Commodity Code |
STEL |
short-term exposure limit |
STP |
standard temperature and pressure |
TC |
toxic concentration |
TCLo |
toxic concentration, low |
TD |
toxic dose |
TDLo |
toxic dose, low |
temp |
temperature(s) |
ThOD |
theoretical oxygen demand |
tid |
three times a day |
TLC |
thin layer chromatography |
TLM |
Threshold Limit, median (aquatic toxicity rating) |
TLV |
Threshold Limit Value |
TLV-C |
Threshold Limit Value-ceiling |
TLV-STEL |
Threshold Limit Value-short term exposure limit |
TLV-TWA |
Threshold Limit Value-time weighted average |
TN |
Tennessee |
TOC |
Total Organic Carbon; threshold odor concentration |
TPA |
terephthalic acid; 12-O-tetradecanoylphorbol-13-acetate |
tRNA |
transfer RNA |
TSCA |
Toxic Substances Control Act (US) |
TSH |
thyrotropin |
TWA |
time weighted average |
TX |
Texas |
u |
micro |
uCi |
microcurie(s) |
UEL |
upper explosive limits |
UFL |
upper flammable limit |
ug |
microgram(s) |
UK |
United Kingdom |
uM |
micromolar |
um |
micron(s) |
umol |
micromole(s) |
UN |
United Nations |
UNEP |
United Nations Environment Programme |
USA/US |
United States of America |
USDA |
US Department of Agriculture |
USEPA |
US Environmental Protection Agency |
USGS |
US Geological Survey |
USITC |
US International Trade Commission |
USP |
US Pharmacopeia |
UT |
Utah |
UV |
ultraviolet |
VA |
Virginia |
vet |
veterinary |
VI |
Virgin Islands |
voc |
volatile organic compound(s) |
vol |
volume |
vp |
vapor pressure |
VT |
Vermont |
w/v |
weight/volume |
w/w |
weight/weight |
WA |
Washington |
WBC |
white blood count |
WHO |
World Health Organization |
WI |
Wisconsin |
wk |
week |
wt |
weight |
WV |
West Virginia |
WY |
Wyoming |
yr |
year |
Go: Guide Index or Back
ALABAMA |
ALASKA |
ARIZONA |
ARKANSAS |
CALIFORNIA |
COLORADO |
CONNECTICUT |
DELAWARE |
FLORIDA |
GEORGIA |
HAWAII |
IDAHO |
ILLINOIS |
INDIANA |
IOWA |
KANSAS |
KENTUCKY |
LOUISIANA |
MAINE |
MARYLAND |
MASSACHUSETTS |
MICHIGAN |
MINNESOTA |
MISSISSIPPI |
MISSOURI |
MONTANA |
NEBRASKA |
NEVADA |
NEW HAMPSHIRE |
NEW JERSEY |
NEW MEXICO |
NEW YORK |
NORTH CAROLINA |
NORTH DAKOTA |
OHIO |
OKLAHOMA |
OREGON |
PENNSYLVANIA |
RHODE ISLAND |
SOUTH CAROLINA |
SOUTH DAKOTA |
TENNESSEE |
TEXAS |
U.S. E.P.A |
UTAH |
VERMONT |
VIRGINIA |
WASHINGTON |
WEST VIRGINIA |
WISCONSIN |
Go: Guide Index or Back
The Hazardous Substances Data Bank (HSDB)
The National Library of Medicine (NLM)
HSDB, from the National Library of Medicine, holds information about the toxicology of over 4,500 potentially hazardous chemicals. In addition to toxicity data, HSDB carries information about emergency handling procedures, environmental fate, human exposure, detection methods, and regulatory requirements. HSDB is fully referenced and peer-reviewed by a Scientific Review Panel composed of expert toxicologists and other scientists.
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Guide Revised October 26, 2005
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