Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation - serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug
This book provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

• All Wiley-Blackwell eBooks Collection( Prod-8204)

• Author/Editor: Han, Chao; Davis, Charles B.; and Wang, Binghe
• ISBN/ISSN: 9780470044919
• Specialty: Pharmacology
• Language:English
• Edition: 1st
• Pages: 289
• Illustrations: 0
• Year: 2009