THE EFFECT OF SOME CURARIZING DRUGS IN UNANAESTHETIZED MAN. I

d-Tubocurarine Chloride, Gallamonium Iodide, Decamethonium Iodide, Succinylcholine Iodide and Its Bis-Monoethyl-Substituted Derivative in Single or Repeated Doses.

From Rigshospitatet, Med. Dept. A, Copenhagen, Denmark. (Head: K. Brøchner-Mortensen).

Present address: Henning Poulsen, Department of Anaesthesiology, University of Aarhus, Denmark.

Willy Hougs, Research Laboratory of GEA, Ltd., Copenhagen F, Denmark.

Aided by a grant from P. Carl Petersen's Foundation.

Received June 14, 1957.

Acta Anaesthesiologica Scandinavica 51(8):p 1018-1042, September 2007.

SUMMARY

Comparative studies on the relaxant effect of d-tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bismonoethyl-substituted derivative in single or repeated intravenous doses were made in 40 normal adult conscious subjects.
Respiration (tidal air and minute volume), voluntary movements (hand and foot), stimulated contractions (fingers), and muscle action potentials were recorded simultaneously.
A comparison between the different methods of measurement of relaxation in humans is made.
“Adequate muscle-paralyzing doses” of the different relaxants are stated.
Differences in the sensitivity to the various relaxants are demonstrated for muscles of the forearm and the leg.
The “respiration-sparing” effect of the relaxants studied is discussed.