Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout

¹Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands,

²Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands,

³Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands,

⁴Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy,

⁵Department of Medicine, University of Colorado Denver, Denver, Colorado, USA,

⁶Department of Biochemistry, University of Otago, Dunedin, New Zealand,

⁷Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia,

⁸Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania,

⁹Department of Internal Medicine, Section of Rheumatology, University Clinic Carl Gustav Carus, Dresden, Saxonia, Germany,

¹⁰Rheumatology and Bone Disease, University of Edinburgh, Edinburgh, UK,

¹¹Department of Medicine, University of Auckland, Auckland, New Zealand,

¹²Department of Medicine, Otago University, Christchurch, Canterbury, New Zealand,

¹³Te Rangawairua o Paratene Ngata Research Centre, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti, New Zealand,

¹⁴Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands,

¹⁵Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Denver, Colorado, USA,

¹⁶Laboratory of Cytokine Immunology, Konkuk University, Seoul, Korea (the Republic of),

¹⁷Department of Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany,