Study of Hypoxia-Induced Expression of HIF-1α in Retina Pigment Epithelium

Yanjun, Zeng
Guangyu, Li
Bin, Fan
Qing, Wang
Ying, Jie
Aizhen, Liu

¹Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing
²Department of Ophthalmology, the Second Hospital of Jilin University, Changchun
³Rehabilitation Engineering Centre, The Hong Kong Polytechnic University, Hong Kong
⁴Department of Optometry, Beijing Tongren Eye Center, Beijing, China

Address for correspondence: e-mail: [email protected]

Bulletin of Experimental Biology & Medicine 143(3):p 323-327, March 2007.

It was shown that the expression of HIF-1α in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1α reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1α decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1α in RPE. It can be an important step in choriodal neovascularization.