Hemostaseological Description of the Heparin-Adenosine Triphosphate (ATP) Complex

Lyapina, L. A.
Pastorova, V. E.
Nikolaeva, L. S.

^*Biology Faculty, Moscow State University, 119899, Vorob'evy Gory, Moscow, Russia.
^**Chemical Faculty, Moscow State University, 119899, Vorob'evy Gory, Moscow, Russia.

Biology Bulletin 32(2):p 179-182, March 2005.

Biochemical methods confirmed the presence of the heparin-ATP complex. Acidic sulfur and carboxyl groups proved to mediate heparin-ATP complex formation. The technique for preparation of the heparin complex at a 1:20 weight ratio of the components and different pH was developed. Intramuscular administration of the resulting complex increased anticoagulant and fibrinolytic activities of animal (rat) plasma. The obtained data indicate the presence of physiologically active heparin-ATP complex providing for anticoagulant effects in the body.