The Consequence of Translesional Replication of Unique UV-Induced Photoproducts

Gentil, Alain
Page, Florence Le
Sarasin, Alain

Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer- IFC1 - C.N.R.S., B.P. n° 8, F-94801 Villejuif Cedex, France

^*Corresponding author

Biological Chemistry 378(11):p 1287-1292, November 1997.

The consequence of translesional replication of unique UV-induced photoproducts is reviewed here. Mutagenesis induced by unique UV-induced lesions, the thymine-thymine dimer (TT) and the thymine-thymine pyrimidine pyrimidone (6-4), [T(6-4)T] carried on single-stranded DNA vectors and replicated in bacteria, yeast and mammalian cells have been considered.

It has been found that in all of the three species the (TT) dimers induce a low mutation frequency compared to the (6-4) photoproduct. The molecular analysis of the mutations induced is reported, showing specific differences depending on the species considered.