Neuronal RNP granules: from physiological to pathological assemblies
- De Graeve, Fabienne
- Besse, Florence
1 Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, F-06100 Nice, France
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Fabienne De Graeve received her PhD in Molecular and Cell Biology in 1999 from the University of Strasbourg, France. She then worked as a postdoctoral researcher in Francesco Ramirez’ group at the Mount Sinai School of Medicine, New-York, USA and in Bernard Dastugue’s group at the University of Clermont Auvergne, France. Since 2004, she is Assistant Professor at the University of Nice Sophia Antipolis, part of University Côte d’Azur, France and joined Florence Besse’s group in 2012 at the Institute of Biology Valrose (iBV), Nice, France.
http://orcid.org/0000-0003-4672-1068
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Florence Besse received her PhD in Cell and Developmental Biology in 2002 from the University Paris 7, France. She then joined Anne Ephrussi’s group at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany as a postdoctoral researcher, then as a staff scientist. In 2009, she launched her group at the Institute of Biology Valrose (iBV), Nice, France. Her laboratory studies the mechanisms of mRNA transport and translation in neurons.
Received January 31, 2018; accepted March 30, 2018; previously published online April 11, 2018
Abstract:
Neuronal cells rely on macro- and micro-cellular compartmentalization to rapidly process information, and respond locally to external stimuli. Such a cellular organization is achieved via the assembly of neuronal ribonucleoprotein (RNP) granules, dynamic membrane-less organelles enriched in RNAs and associated regulatory proteins. In this review, we discuss how these high-order structures transport mRNAs to dendrites and axons, and how they contribute to the spatio-temporal regulation of localized mRNA translation. We also highlight how recent biophysical studies have shed light on the mechanisms underlying neuronal RNP granule dynamic assembly, remodeling and maturation, in both physiological and pathological contexts.