Intraepithelial growth pattern for eyelid sebaceous carcinoma

a cohort of 214 patients from a single institution

  • Zhou, Chuandi
  • Chai, Peiwei
  • Xia, Wenwen
  • Li, Jiang
  • Jia, Renbing
  • Fan, Xianqun

  • 1 Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China

    2 Department of Ophthalmology, Shanghai General Hospital, Shanghai, China

    3 Department of Pathology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China

    4 Department of Oral Pathology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China

Professor Xianqun Fan, Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai 200011, China; [email protected]; Dr Renbing Jia; [email protected]; Dr Jiang Li; [email protected]

Received June 03, 2021

Accepted September 30, 2021

British Journal of Ophthalmology 107(3):p 324-330, March 2023. | DOI: 10.1136/bjophthalmol-2021-319789

Aims

To determine the distribution of three different intraepithelial growth patterns (pagetoid, bowenoid and papillary) in eyelid sebaceous carcinoma (SC) and correlate them with the clinical characteristics and prognosis.

Methods

A retrospective cohort study. The medical charts and pathological sections were retrospectively reviewed. All eligible patients were followed up for recurrence, metastasis and tumour-related mortality. The clinical significance of each intraepithelial growth pattern was determined by Cox regression.

Results

Of the 214 patients, 67 (31%) presented with intraepithelial invasion, among them, 34 (16%) were pagetoid, 27 (13%) were bowenoid and 6 (2.8%) were papillary. Patients of pagetoid intraepithelial spread showed significantly longer diagnostic delay (p=0.001) and more initial misdiagnoses of blepharitis (p=0.035). After a median follow-up period of 34.0 months, 67 (46%) patients in the non-intraepithelial group, 17 (50%) in the pagetoid group, 8 (30%) in the bowenoid group and 2 (33%) in the papillary group recurred. And 30 (20%) patients in the non-intraepithelial group, 9 (27%) in the pagetoid group and 4 (15%) in the bowenoid group developed metastasis. Moreover, 15 (10%) patients in the non-intraepithelial group, 6 (18%) in the pagetoid group and 1 (3.7%) in the bowenoid group died of SC. Cox regression indicated that pagetoid intraepithelial growth pattern was remarkably associated with increased chances of tumour-related mortality (HR=2.95, 95% CI 1.14 to 7.64, p=0.026).

Conclusions

Intraepithelial tumour invasion was presented in nearly one third of patients with eyelid SC. Pagetoid intraepithelial neoplasia, the predominant growth pattern, significantly increased the risk of tumour-related mortality. Meticulous histopathological intraepithelial examination is recommended for every patient of eyelid SC. Special attention should be paid to those with pagetoid invasion, who may require more intensive managements.

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