Review: antidepressants increase clinical response and remission in bipolar depression without increasing induction of maniaAntidepressants for bipolar depression: a systematic review of randomized, controlled trials.

Simon, Gregory E MD, MPH (commentator)
Gijsman, HJ
Geddes, JR
Rendell, JM
et al,

Group Health Cooperative, Seattle, Washington, USA

Gijsman HJ, Geddes JR, Rendell JM, et al. Antidepressants for bipolar depression: a systematic review of randomized, controlled trials. Am J Psychiatry 2004; 161: 1537–47.GijsmanHJGeddesJRRendellJMet alAntidepressants for bipolar depression: a systematic review of randomized, controlled trials.Am J Psychiatry20041611537-47Q What is the efficacy and safety of antidepressants for short term treatment of bipolar depression?

For correspondence: Dr H Gijsman, Warneford Hospital, Oxford, UK. [email protected]

Source of funding: no external funding.

Evidence Based Medicine 10(2):p 45, April 2005.

Clinical impact ratings Psychiatry ★★★★★★☆ GP/FP/Mental health ★★★★★★★