Fluoxetine plus cognitive behavioural therapy was most effective for adolescents with major depressive disorderFluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study TADS randomized controlled trial.

Dubicka, Bernadka MD (commentator)
Ramchandani, Paul MD (commentator)
March, J
Silva, S
Petrycki, S
et al,

¹University of Manchester, Manchester, UK
²University of Oxford, Oxford, UK

March J, Silva S, Petrycki S, et al. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA 2004; 292: 807–20.MarchJSilvaSPetryckiSet alFluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study TADS randomized controlled trial.JAMA2004292807-20Q In adolescents with major depressive disorder (MDD), how do fluoxetine, cognitive behavioural therapy (CBT), and their combination compare for effectiveness?

For correspondence: Dr J S March, Duke University Medical Center, Durham, NC, USA. [email protected]

Sources of funding: National Institute of Mental Health; fluoxetine and placebo provided by Lilly Inc.

Evidence Based Medicine 10(2):p 46, April 2005.

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Mental health ★★★★★★☆ Psychiatry ★★★★★★☆ Paediatrics ★★★★★★☆