Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the kneeEffect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial.

Cranney, Ann MD, MSc (commentator)
O’Donnell, Siobhan PT, MSc (commentator)
Bookman, AA
Williams, KS
Shainhouse, JZ

University of Ottawa Ottawa, Ontario, Canada

Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004; 171: 333–8.BookmanAAWilliamsKSShainhouseJZEffect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial.CMAJ2004171333-8Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD) solution more effective than topical vehicle control (VC) or placebo for providing symptom relief?

For correspondence: Dr. J Z Shainhouse, Dimethaid Health Care Ltd, Markham, Ontario, Canada. Fax 905 415 0827

Source of funding: Dimethaid Health Care.

Evidence Based Medicine 10(3):p 81, June 2005.

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Rheumatology ★★★★★☆☆ Internal Medicine ★★★★★★★