Clopidogrel plus aspirin was inferior to oral anticoagulation for preventing vascular events in atrial fibrillationClopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events ACTIVE W: a randomised controlled trial.

Sloan, Michael A MD, MS (commentator)
The ACTIVE Writing Group on behalf of the ACTIVE Investigators; Connolly, S
Pogue, J
Hart, R
et al,

Carolinas Medical Center, Charlotte, North Carolina, USA

The ACTIVE Writing Group on behalf of the ACTIVE Investigators; Connolly S, Pogue J, Hart R, et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet 2006;367: 1903–12.The ACTIVE Writing Group on behalf of the ACTIVE Investigators; ConnollySPogueJHartRet alClopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events ACTIVE W: a randomised controlled trial.Lancet20063671903-12

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★☆ Cardiology ★★★★★★☆ Haematology ★★★★★★★

Sources of funding: Sanofi Aventis and Bristol Myers Squibb.

Sources of funding: Sanofi-Aventis and Bristol-Myers Squibb

Evidence Based Medicine 11(6):p 170, December 2006.