Adjunctive inhaled insulin before meals improved glycaemic control more than adjunctive metformin in type 2 diabetes mellitusAn open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin Exubera with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.

Kudva, Yogish C MBBS (commentator)
Basu, Ananda MBBS (commentator)
Barnett, AH
Dreyer, M
Lange, P
et al,

Mayo Clinic, Rochester, Minnesota, USA

Barnett AH, Dreyer M, Lange P, et al. An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea. Diabetes Care 2006;29: 1282–7.BarnettAHDreyerMLangePet alAn open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin Exubera with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.Diabetes Care2006291282-7

Clinical impact ratings GP/FP/Primary care ★★★★★★★ IM/Ambulatory care ★★★★★☆☆ Endocrine ★★★★★★

For correspondence: Dr A H Barnett, Birmingham Heartlands Hospital, Birmingham, UK. [email protected]

Source of funding: Pfizer.

Evidence Based Medicine 11(6):p 176, December 2006.