Daily oral vitamin B-12 with or without folic acid for 24 weeks did not improve cognitive function in elderly peopleEffect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.

Lee, Philip E MD (commentator)
Rochon, Paula A MD (commentator)
Eussen, SJ
de Groot, LC
Joosten, LW
et al,

¹University of British Columbia, Vancouver, British Columbia, Canada
²University of Toronto, Toronto, Ontario, Canada

Eussen SJ, de Groot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006;84: 361–70.EussenSJde GrootLCJoostenLWet alEffect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.Am J Clin Nutr200684361-70

Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM/Ambulatory care ★★★★☆☆☆ Neurology ★★★★★☆☆ Geriatrics ★★★★☆☆☆

For correspondence: Dr L C de Groot, Wageningen University, Wageningen, The Netherlands. [email protected]

Sources of funding: ZON-MV; Kellogg’s Benelux; Foundation to Promote Research Into Functional Vitamin B12 Deficiency and the European Union BIOMED Demonstration Project; Nutricia Health Foundation.

Evidence Based Medicine 12(1):p 18, February 2007.