Remyelination of chronic demyelinated lesions with directly induced neural stem cells
- Peruzzotti-Jametti, Luca
- Vicario, Nunzio
- Volpe, Giulio
- Rizzi, Sandra
- Kwok, Cheek
- Lombardi, Ivan
- Bergholt, Mads S
- Barea-Moya, Lucas
- D’Angelo, Andrea
- Nicaise, Alexandra M
- D’Amico, Giuseppe
- Krzak, Grzegorz
- Willis, Cory M
- Gil-Perotin, Sara
- Hruba, Olena
- Braga, Alice
- Stevens, Molly M
- Garcia-Verdugo, José M
- Saeb-Parsy, Kourosh
- Zhao, Chao
- Franklin, Robin J M
- Edenhofer, Frank
- Pluchino, Stefano
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, Catania I-95123, Italy
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Institute of Molecular Biology & CMBI, Genomics, Stem Cell Biology & Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck 6020, Austria
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg 97070, Germany
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano 20126, Italy
Centre for Craniofacial & Regenerative Biology, King’s College London, London WC2R 2LS, UK
Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK
Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia and CIBERNED-ISCIII, Valencia 46980, Spain
Research Group in Immunotherapy and Biomodels of Autoimmunity, Health Research Institute La Fe, Valencia 46026, Spain
Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia 46026, Spain
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia and CIBERNED-ISCIII, Valencia 46980, Spain
Research Group in Immunotherapy and Biomodels of Autoimmunity, Health Research Institute La Fe, Valencia 46026, Spain
Red Española de Terapias Avanzadas, TERAV-RICORS, RD24/0014/0009, Instituto de Salud Carlos III, Sevilla 41092, Spain
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK
Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia and CIBERNED-ISCIII, Valencia 46980, Spain
Department of Surgery, Cambridge Biomedical Research Centre, University of Cambridge, Cambridge CB2 0QQ, UK
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK
Institute of Molecular Biology & CMBI, Genomics, Stem Cell Biology & Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck 6020, Austria
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg 97070, Germany
Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge CB2 0AH, UK
Correspondence to: Stefano Pluchino Department of Clinical NeurosciencesUniversity of Cambridge, Clifford Allbutt BuildingHills Road, Cambridge CB2 0AH, UK E-mail: [email protected]
Correspondence may also be addressed to: Luca Peruzzotti-Jametti E-mail: [email protected]
Received November 15, 2024
Received in revised form March 27, 2025
Accepted May 06, 2025
Revised July 07, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
