Apolipoprotein E and Its Association With Cognitive Change and Modification of Treatment Effects of Vitamin D3 and Omega-3s on Cognitive Change

Results From the In-Clinic Subset of a Randomized Clinical Trial

Vyas, Chirag M MBBS, MPH
Kang, Jae H ScD
Mischoulon, David MD, PhD
Cook, Nancy R ScD
Reynolds, Charles F III MD
Chang, Grace MD, MPH
Mora, Samia MD, MHS
De Vivo, Immaculata PhD
Manson, JoAnn E MD, DrPH
Okereke, Olivia I MD, SM

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Department of Psychiatry, UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts, USA
Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
(Medical Sciences Section)

Address correspondence to: Chirag M. Vyas, MBBS, MPH. E-mail: [email protected]

Received July 14, 2023

Revised February 19, 2024

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

The Journals of Gerontology: Series A 79(3), March 2024. | DOI: 10.1093/gerona/glad260