Lipase catalysed amidation of diethyl glutamate derivatives

peculiarities of ethyl S- and R-pyroglutamate

Conde, Santiago
López-serrano, Paloma
Martínez, Ana

Instituto de Química Médica (C.S.I.C.). Juan de la Cierva 3. 20006 Madrid Spain

Biotechnology Letters 20(3):p 261-263, March 1998.

Candida antarctica lipase mediated amidation of both ethyl S- and R-pyroglutamate at 60°C takes place in less than 5 minutes. Kinetic differences, S-enantiomer rate higher than that of R, appeared when the reaction was performed at 45°C.