Resolution of (±)-trans-2-phenylcyclohexan-1-ol by lipases from Candida rugosa

effect of catalyst source and reaction conditions

Río, José Luis Del
Faus, Ignacio

Laboratory of Biotechnolody, URQUIMA, S.A. (URIACH GROUP), Arnau de Vilanova, 22–42, 08105 Sant Fost de Campsentelles Barcelona Spain

Biotechnology Letters 20(11):p 1021-1025, November 1998.

Candida rugosa lipase resolved trans-2-phenylcyclohexan-1-ol. A commercial and a laboratory preparation were compared and better results were obtained with the latter (E >200). Both enzyme preparations were strongly dependent on the substrate concentration for their enantioselectivity. This effect could be due to the presence of an esterase activity unspecific for trans-2-phenylcyclohexan-1-ol.