Analysis of the Cutoff Values in Fibrin-Related Markers for the Diagnosis of Overt DIC

  • Hatada, Tsuyoshi
  • Wada, Hideo
  • Kawasugi, Kazuo
  • Okamoto, Kohji
  • Uchiyama, Toshimasa
  • Kushimoto, Shigeki
  • Seki, Yoshinobu
  • Okamura, Takashi
  • Imai, Hiroshi
  • Kaneko, Toshihiro
  • Nobori, Tsutomu

  • 1Emergency Critical Care Center, Mie University Hospital, Tsu, Japan

    2Department of Molecular and Laboratory Medicine, Mie University School of Medicine, Tsu, Japan

    3Department of Internal Medicine, Teikyo University School of Medicine, Itabashi, Japan

    4First Department of Surgery, University of Occupational and Environmental Health School of Medicine, KitaKyushu, Japan

    5Department of Internal Medicine, National Hospital Organization Takasaki General Medical Center, Takasaki, Japan

    6Department of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan

    7Department of Internal Medicine, Shibata Hospital-Niigata Prefectural Hospital, Shibata, Japan

    8Department of Medicine, Division of Hematology and Oncology, Kurume University School of Medicine, Kurume, Japan

    9Patient Safety Division, Mie University Graduate School of Medicine, Tsu, Japan

Corresponding Author:

Hideo Wada, Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan

Email: [email protected]

Clinical & Applied Thrombosis/Hemostasis 18(5):p 495-500, September-October 2012. | DOI: 10.1177/1076029611429786

Abstract

Fibrin-related markers (FRMs) such as fibrin and fibrinogen degradation products (FDPs), D-dimer, and soluble fibrin monomer complex (SFMC) were prospectively evaluated in 522 patients using the overt disseminated intravascular coagulation (DIC) diagnostic criteria. The differences in all FRMs between the DIC group and the non-DIC group, and those between the survivors and nonsurvivors were significant in the patients with infections. In an analysis of all patients, DIC score cutoff values of 2 and 3 points for FDP, D-dimer, and SFMC were recommended to be 8.3 and 42.0 μg/mL, 2.4 and 22.0 μg/mL, and 3.4 and 138.0 μg/mL, respectively. In conclusion, the adequate cutoff value is thus considered to be useful for both making a diagnosis of DIC and for predicting the outcome. Fibrin-related markers are therefore thought to be more useful for making a diagnosis of DIC based on infections than based on any other underlying disorders.

Copyright ©2012Sage Publications