Seasonality of Both Bacteremic and Nonbacteremic Pneumonia Coincides With Viral Lower Respiratory Tract Infections in Early Childhood, in Contrast to Nonpneumonia Invasive Pneumococcal Disease, in the Pre-Pneumococcal Conjugate Vaccine Era

Ben-Shimol, Shalom
Greenberg, David
Hazan, Guy
Shemer-Avni, Yonat
Givon-Lavi, Noga
Dagan, Ron

¹The Pediatric Infectious Disease Unit, Soroka University Medical Center
²The Faculty of Health Sciences, Ben-Gurion University
³Laboratory of Clinical Virology, Soroka University Medical Center, Beer-Sheva, Israel

Correspondence: Ron Dagan, MD, The Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel ([email protected]).

Received September 14, 2014

Accepted January 2, 2015

Clinical Infectious Diseases 60(9):p 1384-1387, May 01, 2015. | DOI: 10.1093/cid/civ023

We assessed the seasonality of viral lower respiratory tract infections (V-LRI), bacteremic pneumonia, nonbacteremic pneumonia and nonpneumonia invasive pneumococcal diseases (IPD) in the pre-PCV era. Both bacteremic and nonbacteremic pneumonia seasonality peaked in winter, coinciding with V-LRI seasonality, whereas non-pneumonia IPD peaked in autumn before V-LRI increase, suggesting different pathogenesis.