Aspirin and Statin Nonuse Associated With Early Biochemical Failure After Prostate Radiation Therapy

Kanani, Samir P. MD

Associate Clinical Professor of Neurosurgery and Radiation Oncology, George Washington University; Radiation Oncology, Inova Fairfax Hospital, Falls Church, VA

Dr. Kanani reports no financial relationships relevant to this field of study.

Clinical Oncology Alert 28(7):p 51-52, July 2012.

SYNOPSIS: In a large retrospective series, 2051 men with clinically localized prostate cancer received definitive radiation therapy (RT) alone. The rates of aspirin use and statin use were 36% and 34%, respectively. The primary endpoint was IBF (interval to biochemical failure) of < 18 months. With a median follow-up of 75 months, univariate analysis demonstrated that an IBF of < 18 months was associated with aspirin nonuse, statin nonuse, anticoagulant nonuse, cardiovascular disease, and PSA, but not Gleason score, age, RT dose, or T stage. On multivariate analysis, only aspirin nonuse and statin nonuse were associated with an IBF of < 18 months.

SOURCE: Zaorsky NG, et al. Aspirin and statin nonuse associated with early biochemical failure after prostate radiation therapy. Int J Radiation Biol Phys 2012; [Epub ahead of print].