New insights into the mechanism of action of acetaminophen

Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

  • Aronoff, David M. MD
  • Oates, John A. MD
  • Boutaud, Olivier PhD

  • Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Mich, and Departments of Internal Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn

Reprint requests: Olivier Boutaud, PhD, Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602.

E-mail: [email protected]

Financial support was provided by National Institutes of Health grants HL007749 and GM15431, the Parker B. Francis Foundation, and grants from Merck-Frosst and McNeil.

Received for publication July 25, 2005; accepted Sept 15, 2005.

Clinical Pharmacology & Therapeutics 79(1):p 9-19, January 2006.
Copyright © Mosby-Year Book Inc. 2006. All Rights Reserved.