A cell membrane like biomimetic drug-eluting coronary stent**☆
- Fan, De-zeng
- Yan, Xin-hao
- Bian, Hui-juan
- Cai, Chen-shui
- Sun, Fu-yu
- Ji, Jian
- Xu, Jian-ping
- Jin, Qiao
- Shen, Jia-cong
- Qiu, Hong
- Gao, Run-lin
Abstract
BACKGROUND:
The restenosis occurs up to 20%-30% following metal coronary stent implantation. Under the support of the 863 program, the feasibility to treat coronary artery stenosis using a novel drug-eluting stent (DES) has been investigated to reduce restenosis.
OBJECTIVE:
A drug-eluting stent (rapamycin as drug mode) was implanted into porcine models of coronary stenosis. The safety and efficacy of the drug-eluting stent were observed and compared with bare-metal stent.
DESIGN, TIME AND SETTING:
A randomized controlled animal experiment was performed in the Fu Wai Hospital for Cardiovascular Disease between November 2003 and April 2004.
MATERIALS:
A novel bioinspired phospholipid copolymer was synthesized by free radical polymerization of stearyl methacrylate, β -hydroxypropyl methacrylateand 3-(trimethoxysilyl) propylmethacrylate.
METHODS:
Twenty-one pigs were randomly divided into 3 groups: bare-mental stent, drug-eluting stent, and polymer-coated stent. The treated stents pre-loaded onto a delivery system through the use of crimping instrument were implanted into pig's coronary artery, with 2 stents per pig.
MAIN OUTCOME MEASURES:
Determination of luminal diameter, luminal area, mean intimal thickness on and between the stents, neointimal area, percentage of luminal area restenosis, and damage index using an image analysis instrument.
RESULTS:
At 28 days after implantation, there was significant difference in mean intimal thickness on and between the stents, as well as neointimal area, between the DES and bare-metal stent groups (P < 0.05). The neointimal area was reduced by 44.87% in the DES group compared with the bare-metal stent group. No significant difference in percentage of luminal area restenosis was found between the DES and bare-metal stent groups, but P value equaled to 0.053, which was close to 0.05. In addition, no restenosis was found in the DES group.
CONCLUSION:
Rapamycin DES can markedly resist intravascular intimal hyperplasia and restenosis following stenting.