SymbolCalcineurin inhibitors-induced nephrotoxicity: Early prevention and treatment following renal transplantation
- Bao, Ze-qing
- Shi, Lei
- Zhao, Shu-jin
Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China
Bao Ze-qing, Studying for master's degree, Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China [email protected]
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Correspondence to: Zhao Shu-jin, Professor, Doctoral supervisor, Chief physician, Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China [email protected]
Supported by: the Plan for Social Development of Science and Technology Plan Project of Guangdong Province, No.2005B30701004*
Received:2010-01-05
Accepted:2010-04-28
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Abstract
OBJECTIVE:
To review the prevention and treatment for calcineurin inhibitors-induced nephrotoxicity.
METHODS:
Using key words of “Ciclosporine A, Tacrolimus, CNIS drug-induced chronic nephrotoxicity”, documents published between January 1980 and January 2010 in databases of PubMed and CNKI were searched. Totally 44 articles closely related to calcineurin inhibitors-induced nephrotoxicity were reviewed.
RESULTS:
Ciclosporin and tacrolimus were often employed as immunosuppressants, which notably improve life quality and survival rates of transplant recipients. However, long-term use of calcineurin inhibitors caused a characteristic type of chronic nephrotoxicity after renal transplantation and resulting in a decline of renal function. Currently, it has been confirmed that chronic allograft nephropathy and calcineurin inhibitors-induced nephrotoxicity are the main reasons for graft failure. The calcineurin inhibitors-induced nephrotoxicity plays an important role in natural course of chronic allograft nephropathy.
CONCLUSION:
There is not an effective method for preventing or treating calcineurin inhibitors-induced nephrotoxicity. Thus, it may be a good choice for preventing calcineurin inhibitors-induced nephrotoxicity by reducing dose or withdraw of calcineurin inhibitors.
Bao ZQ, Shi L, Zhao SJ. Calcineurin inhibitors-induced nephrotoxicity: Early prevention and treatment following renal transplantation. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2010;14(44): 8297-8302. [http://www.crter.cnhttp://en.zglckf.com]
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