Second-generation antihistamines have similar efficacy in allergic rhinitis, but their tolerability and metabolism differ

Allergic rhinitis is a common condition characterised predominantly by nasal congestion and is often associated with a reduced health-related quality of life. Second-generation H₁ receptor antagonists, which are much better tolerated than first-generation antihistamines, are often used as first-line treatment. Comparative studies of the second-generation H₁ antihistamines have shown similar efficacy, but different tolerability profiles