Methylprednisolone was associated with an increase in death after head injuryEffect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury MRC CRASH trial: randomised placebo-controlled trial.

Thompson, Hilaire J RN, CNRN, PhD (commentator)
Bakshi, Asha MD (commentator)

¹School of Nursing, University of Washington Seattle, Washington, USA
²Department of Neurosurgery, University of Pennsylvania Philadelphia, Pennsylvania, USA

CRASH Trial Collaborators. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004; 364: 1321–8.CRASH Trial CollaboratorsEffect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury MRC CRASH trial: randomised placebo-controlled trial.Lancet20043641321-8Q In patients with head injury, is early administration of methylprednisolone better than placebo for reducing death?

For correspondence: CRASH Trials Coordinating Centre, London School of Hygiene and Tropical Medicine, London, UK. [email protected]

Sources of funding: UK Medical Research Council, Pharmacia and Upjohn .

Evidence-Based Nursing 8(2):p 51, April 2005.