Machine learning to optimize use of natriuretic peptides in the diagnosis of acute heart failure
- Doudesis, Dimitrios
- Lee, Kuan Ken
- Anwar, Mohamed
- Singer, Adam J
- Hollander, Judd E
- Chenevier-Gobeaux, Camille
- Claessens, Yann-Erick
- Wussler, Desiree
- Weil, Dominic
- Kozhuharov, Nikola
- Strebel, Ivo
- Sabti, Zaid
- deFilippi, Christopher
- Seliger, Stephen
- Mesquita, Evandro Tinoco
- Wiemer, Jan C
- Möckel, Martin
- Coste, Joel
- Jourdain, Patrick
- Kimiaki, Komukai
- Yoshimura, Michihiro
- Ibrahim, Irwani
- Ooi, Shirley Beng Suat
- Kuan, Win Sen
- Gegenhuber, Alfons
- Mueller, Thomas
- Hanon, Olivier
- Vidal, Jean-Sébastien
- Cameron, Peter
- Lam, Louisa
- Freedman, Ben
- Chung, Tommy
- Collins, Sean P
- Lindsell, Christopher J
- Newby, David E
- Japp, Alan G
- Shah, Anoop S V
- Villacorta, Humberto
- Richards, A Mark
- McMurray, John J V
- Mueller, Christian
- Januzzi, James L
- Mills, Nicholas L
- Moe, Gordon
- Fernando, Carlos
- Gaggin, Hanna K
- Bayes-Genis, Antoni
- van Kimmenade, Roland RJ
- Pinto, Yigal
- Rutten, Joost HW
- van den Meiracker, Anton H
- Gargani, Luna
- Pugliese, Nicola R
- Pemberton, Christopher
- Neumaier, Michael
- Behnes, Michael
- Akin, Ibrahim
- Bombelli, Michele
- Grassi, Guido
- Nazerian, Peiman
- Albano, Giovanni
- Bahrmann, Philipp
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
Usher Institute, University of Edinburgh, Edinburgh EH16 4UX, UK
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
Department of Emergency Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, USA
Department of Emergency Medicine, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, USA
Department of Biochemistry, Cochin Hospital, Assistance Publique-Hopitaux de Paris, Paris, France
Department of Emergency Medicine, Princess Grace Hospital Center, Monaco, Principalty of Monaco
Department of Cardiology, Cardiovascular Research Institute of Basel, University Hospital Basel, Basel, Switzerland
Department of Internal Medicine, University Hospital Basel, University of Basel, Basel, Switzerland
Department of Cardiology, Cardiovascular Research Institute of Basel, University Hospital Basel, Basel, Switzerland
Department of Cardiology, Cardiovascular Research Institute of Basel, University Hospital Basel, Basel, Switzerland
Liverpool Heart and Chest Hospital, Liverpool L14 3PE, UK
Department of Cardiology, Cardiovascular Research Institute of Basel, University Hospital Basel, Basel, Switzerland
Department of Cardiology, Cardiovascular Research Institute of Basel, University Hospital Basel, Basel, Switzerland
Division of Cardiology, University of Maryland School of Medicine, Baltimore, USA
Division of Nephrology, University of Maryland School of Medicine, Baltimore, USA
Cardiology Division, Fluminense Federal University, Niteroi, Rio de Janeiro State, Brazil
B·R·A·H·M·S, Thermo Fisher Scientific, Hennigsdorf, Germany
Department of Emergency and Acute Medicine with Chest Pain Units, Charité—Universitätsmedizin Berlin, Campus Mitte and Virchow, Berlin, Germany
Biostatistics and Epidemiology Unit, Cochin Hospital, Paris, France
Cardiology Department, AP-HP, Paris-Saclay University, Paris, France
Division of Cardiology, The Jikei University Kashiwa Hospital, Kashiwa, Japan
Division of Cardiology, The Jikei University Kashiwa Hospital, Kashiwa, Japan
Emergency Medicine Department, National University Hospital, Singapore, Singapore
Emergency Medicine Department, National University Hospital, Singapore, Singapore
Emergency Medicine Department, National University Hospital, Singapore, Singapore
Department of Internal Medicine, Krankenhaus Bad Ischl, Bad Ischl, Austria
Department of Laboratory Medicine, Hospital Voecklabruck, Voecklabruck, Austria
Department of Geriatrics, Broca Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
Department of Geriatrics, Broca Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia
Heart Research Institute, University of Sydney, Sydney, Australia
Department of Cardiology, Concord Repatriation General Hospital, Sydney, Australia
Department of Emergency Medicine, Vanderbilt University Medical Center, and Veterans Affairs Tennessee Valley Healthcare System, Geriatric Research, Education and Clinical Center (GRECC), Nashville, TN, USA
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
Department of Non Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
Cardiology Division, Fluminense Federal University, Niteroi, Rio de Janeiro State, Brazil
Christchurch Heart Institute, University of Otago, Christchurch, New Zealand
Cardiovascular Research Institute, National University Heart Centre Singapore, Singapore
BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Department of Cardiology, Cardiovascular Research Institute of Basel, University Hospital Basel, Basel, Switzerland
Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Bain Institute for Clinical Research, Boston, MA, USA
Heart Failure and Biomarker Trials, Baim Institute for Clinical Research, Boston, MA, USA
British Heart Foundation (BHF) Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SA, UK
Usher Institute, University of Edinburgh, Edinburgh EH16 4UX, UK
Corresponding author. Tel: 0131 242 6517, Emails: [email protected]; [email protected]
Dimitrios Doudesis and Kuan Ken Lee contributed equally to the study.
Listed in the Supplementary Appendix.
Collaborators:
Gordon Moe, MD, Carlos Fernando, MD, Hanna K Gaggin, MD, Antoni Bayes-Genis, MD, Roland RJ van Kimmenade, MD, Yigal Pinto, MD, Joost HW Rutten, MD, Anton H. van den Meiracker, MD, Luna Gargani, MD, Nicola R Pugliese, MD, Christopher Pemberton, PhD, Michael Neumaier, MD, Michael Behnes, MD, Ibrahim Akin, MD, Michele Bombelli, MD, Guido Grassi, MD, Peiman Nazerian, MD, Giovanni Albano, MD, Philipp Bahrmann, MD
Conflict of interest: A.B.-G. reports personal fees and non-financial support from Roche Diagnostics, during the conduct of the study; personal fees from Abbott, personal fees from AstraZeneca, grants, personal fees and non-financial support from Boehringer-Ingelheim, personal fees and non-financial support from Novartis, personal fees and non-financial support from Vifor, outside the submitted work. J.C.W. reports work as a biostatistician at the biotech company B·R·A·H·M·S GmbH, part of Thermo Fisher Scientific. M.M. reports grants from Health Care Research Projects, grants from Biomarker Research, personal fees from Consulting, outside the submitted work. A.S.V.S. reports speaker fees from Abbott Diagnostics, outside the submitted work. A.G.J. reports speaker fees/consultancy fees from Astra Zeneca, Novartis, Vifor, Bayer and Pharmacosmos. H.V. reports speaker fees and consulting fees from Roche Diagnostics and speaker fees from Novartis, AstraZeneca, Boehringer Ingelheim, Servier, Bayer, and Daiichi Sankyo, outside the submitted work. A.M.R. reports grants, personal fees and non-financial support from Roche Diagnostics, outside the submitted work. J.J.V.M. reports consulting fees from Alnylam, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Cardurion, Dal-Cor, GSK, Ionis, KBP Biosciences, Novartis, Pfizer, Theracos, payments for advisory boards, symposia or lectures from Abbott, Alkem Metabolics, Canadian Medical & Surgical Knowledge Translation Research Group, Eris Lifesciences, Hikma, Lupin, Sun Pharmaceuticals, Medscape/Heart.Org, ProAdWise Communications, Radcliffe Cardiology, Servier, the Corpus, participation on a Data Safety Monitoring Board or Advisory Board for Cardialysis (MONITOR study) and Merck (VICTORIA trial) and work as company director for Global Clinical Trial Partners Ltd, outside the submitted work. C.M. reports grants and non-financial support from several diagnostic companies during the conduct of the study; grants, personal fees and non-financial support from several diagnostic companies, outside the submitted work. N.L.M. reports speaker fees from Abbott Diagnostics and Siemens Healthineers, and personal fees for consultancy or advisory boards from Roche Diagnostics and LumiraDx, outside the submitted work. K.K.L., D.D., and N.L.M. are employed by the University of Edinburgh, who has filed a patent on the CoDE-HF score (UK Intellectual Property Office Reference: PCT/GB2021/051470). J.J. is a trustee of the American College of Cardiology; is a board member of Imbria Pharmaceuticals; has received grant support from Abbott, Applied Therapeutics, HeartFlow, Innolife, and Roche Diagnostics; has received consulting income from Abbott, Beckman, Boehringer Ingelheim, Bristol Myers Squibb, Janssen, Jana Care, Merck, Novartis, Pfizer, Roche Diagnostics, and Siemens; and participates in clinical endpoint committees/data safety monitoring boards for Abbott, AbbVie, CVRx, Intercept, and Takeda. S.P.C. receives research support from NIH, PCORI, DOD and AHRQ and serves as a consultant for Reprieve Cardiovascular and Abbott. C.J.L. reports grants to institution from NIH, CDC and DoD, contracts to institution from Entegrion, Endpoint Health, BioMerieux, Biomeme, Novartis, and AstraZeneca, income from VUMC, Emory University and Rocket Pharmaceuticals for research services, stock options in Bioscape Digital, patents for risk stratification in sepsis and septic shock held by Cincinnati Children’s Hospital Medical Centre, and income from ACTS for service as Editor-In-Chief of the Journal of Clinical and Translational Science.
Received February 19, 2025
Accepted February 25, 2025
Revised April 25, 2025
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