Library approaches to biophysical problems

Thomas J. Magliery was born in Oak Park, Illinois, and received his AB in chemistry from Kenyon College, Gambier, Ohio. He received his PhD from the University of California, Berkeley, under the direction of Peter G. Schultz, developing combinatorial methodology that led to the first bacteria able to site-specifically insert unnatural amino acids into proteins. He has worked with Lynne Regan at Yale University for the last two years on combinatorial methods to address biophysical problems, including the role of protein cores in stability, methods to identify interacting proteins and applications of statistical methods to protein design.

Lynne Regan is Professor of Molecular Biophysics & Biochemistry and Professor of Chemistry at Yale University. She received her BA from Oxford University in biochemistry and her PhD in biology from the Massachusetts Institute of Technology under the direction of Paul Schimmel. She did postdoctoral work as a visiting scientist with William F. DeGrado before starting her group at Yale in 1990. Her research interests encompass many aspects of protein structure, folding and design with particular emphasis on protein–protein and protein·RNA interactions.