Progression of potentially aggressive pituitary neuroendocrine tumors after radiotherapy

risk factors, management, and outcomes

Bioletto, Fabio Data curation; Formal analysis; Writing - original draft
Bogeat, Caroline Data curation; Formal analysis; Writing - review & editing
Barat, Maxime Data curation; Writing - review & editing
Benanteur, Nesrine Formal analysis; Writing - review & editing
Guignat, Laurence Writing - review & editing
Hage, Mirella Writing - review & editing
Garcia, Cyril Writing - review & editing
Calugaru, Valentin Data curation; Writing - review & editing
Jacob, Julian Writing - review & editing
Arrondeau, Jennifer Writing - review & editing
Groussin, Lionel Writing - review & editing
Bertagna, Xavier Writing - review & editing
Bertherat, Jérôme Writing - review & editing
Villa, Chiara Writing - review & editing
Jouinot, Anne Formal analysis; Writing - review & editing
Baussart, Bertrand Conceptualization; Supervision; Writing - review & editing
Assié, Guillaume Conceptualization; Supervision; Writing - original draft; Writing - review & editing

Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
Department of Endocrinology, Diabetology and Nutrition, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, 92100 Boulogne Billancourt, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Radiology, Hôpital Cochin, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Endocrinology, Hôpital Cochin, Reference and Competence Center for Rare Adrenal Diseases and Rare Pituitary Diseases, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France
Department of Endocrinology, Diabetology and Nutrition, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, 92100 Boulogne Billancourt, France
Université de Versailles Saint-Quentin-en-Yvelines, UFR des Sciences de la Santé Simone Veil, 78180 Montigny-le-Bretonneux, France
Service D’Endocrinologie, Hôpital National D’Instruction des Armées Bégin, 94160 Saint-Mandé, France
Department of Radiation Oncology, Paris/Saint-Cloud/Orsay, Institut Curie, PSL Research University, 75005 Paris, France
Department of Radiation Oncology, Hôpital La Pitié-Salpêtrière, Assistance Publique–Hôpitaux de Paris, 75013 Paris, France
Department of Clinical Oncology, Hôpital Cochin, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Endocrinology, Hôpital Cochin, Reference and Competence Center for Rare Adrenal Diseases and Rare Pituitary Diseases, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Endocrinology, Hôpital Cochin, Reference and Competence Center for Rare Adrenal Diseases and Rare Pituitary Diseases, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Endocrinology, Hôpital Cochin, Reference and Competence Center for Rare Adrenal Diseases and Rare Pituitary Diseases, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Pathology, Hôpital Lariboisière, Assistance Publique–Hôpitaux de Paris, 75010 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Neurosurgery, Hôpital Lariboisière, Assistance Publique–Hôpitaux de Paris, 75010 Paris, France
Université Paris Cité, CNRS UMR8104, INSERM U1016, Institut Cochin, 75014 Paris, France
Department of Endocrinology, Hôpital Cochin, Reference and Competence Center for Rare Adrenal Diseases and Rare Pituitary Diseases, Assistance Publique–Hôpitaux de Paris, 75014 Paris, France

Corresponding author: Department of Endocrinology, Hôpital Cochin, Reference and Competence Center for Rare Adrenal Diseases and Rare Pituitary Diseases, Assistance Publique–Hôpitaux de Paris, 27 rue du Faubourg-Saint-Jacques, 75014 Paris, France. Email: [email protected]

Fabio Bioletto and Caroline Bogeat contributed equally and share first authorship.

Bertrand Baussart and Guillaume Assié contributed equally and share last authorship.

Conflict of interest: G.A. is on the editorial board of EJE. He was not involved in the review or editorial process for this paper, on which he is listed as author.

Received February 17, 2025

Received in revised form May 10, 2025

Revised July 24, 2025

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

European Journal of Endocrinology 193(1):p 167-178, July 2025. | DOI: 10.1093/ejendo/lvaf136