Tubby-tagged balancers for the Drosophila X and second chromosomes

  • Lattao, Ramona
  • Bonaccorsi, Silvia
  • Guan, Xiao
  • Wasserman, Steven A.
  • Gatti, Maurizio

  • 1Dipartimento di Biologia e Biotecnologie “Charles Darwin” and Istituto di Biologia e Patologia Molecolari del CNR; Sapienza, Università di Roma; Rome, Italy; 2Section of Cell and Developmental Biology; University of California; La Jolla, CA USA

*Correspondence to: Maurizio Gatti; Email: [email protected] Submitted: 05/31/11; Revised: 07/06/11; Accepted: 07/07/11 http://dx.doi.org/10.4161/fly.5.4.17283

Fly 5(4):p 369-370, October-November-December 2011.

We generatedFM7aandCyObalancer chromosomes bearing aTubby (Tb) dominant transgene. Flies heterozygous for these FM7a and CyO derivatives exhibit a phenotype undistinguishable from that elicited by the Tb mutation associated with the TM6B balancer. We tested two of these Tb-bearing balancers (FM7-TbA and CyO -TbA) for more than 30 generations and found that the Tb transgene they carry is stable. Thus, these new Tb-tagged balancers are particularly useful for balancing lethal mutations and distinguish homozygous mutant larvae from their heterozygous siblings.

Copyright © 2011 Landes Bioscience
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