Higher Prevalence of Monogenic Cause Among Very Early Onset Inflammatory Bowel Disease in Children
Experience From a Tertiary Care Center From Northern India
- Poddar, Ujjal MD, DNB, DM
- Aggarwal, Amita MD, DM
- Jayalakshmi, Krishnegowda MD
- Sarma, Moinak Sen MD, DM
- Srivastava, Anshu MD, DM
- Rawat, Amit MD
- Yachha, Surender Kumar MD, DM
Inflammatory Bowel Diseases 29(10):p 1572-1578, October 03, 2023. | DOI: 10.1093/ibd/izac254
Lay Summary
Of 200 children with inflammatory bowel disease (IBD), 48 were very early-onset IBD (VEO-IBD) and 15 (32%) of them had monogenic VEO-IBD. Clinical features that differentiated monogenic from nonmonogenic VEO-IBD were neonatal onset, perianal disease, history of consanguinity and sibling death, wasting, stunting, and IBD unclassified phenotype.
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