Creeping Fat in the Pathogenesis of Crohn’s Disease

An Orchestrator or a Silent Bystander?

Tsounis, Efthymios P MSc
Aggeletopoulou, Ioanna PhD
Mouzaki, Athanasia PhD
Triantos, Christos PhD

Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, Patras 26504, Greece
Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, Patras 26504, Greece
Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece
Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece
Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, Patras 26504, Greece

Address correspondence to: Christos Triantos, Associate Professor in Internal Medicine and Gastroenterology, D. Stamatopoulou 4, Rio 26504, Patras, Greece ([email protected]; [email protected]).

Received November 21, 2022

Revised June 01, 2023

Online date: June 01, 2023

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Inflammatory Bowel Diseases 29(11):p 1826-1836, November 02, 2023. | DOI: 10.1093/ibd/izad095

Lay Summary

Creeping fat, a common feature of Crohn’s disease, is the wrapping of mesenteric fat around the intestinal wall, resulting in mucosal response aggravation and lesion exacerbation through releasing pro-inflammatory molecules and cells to the gut, leading to worsened disease course.