Higher Prevalence of Monogenic Cause Among Very Early Onset Inflammatory Bowel Disease in Children

Experience From a Tertiary Care Center From Northern India

Poddar, Ujjal MD, DNB, DM
Aggarwal, Amita MD, DM
Jayalakshmi, Krishnegowda MD
Sarma, Moinak Sen MD, DM
Srivastava, Anshu MD, DM
Rawat, Amit MD
Yachha, Surender Kumar MD, DM

Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Pediatric Allergy and Immunology Division, Department of Pediatrics, Advanced Pediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

Address correspondence to: Ujjal Poddar, MD, DNB, DM, Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow, 226014, Uttar Pradesh, India ([email protected]).

Received October 07, 2022

Online date: January 03, 2023

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Inflammatory Bowel Diseases 29(10):p 1572-1578, October 03, 2023. | DOI: 10.1093/ibd/izac254

Lay Summary

Of 200 children with inflammatory bowel disease (IBD), 48 were very early-onset IBD (VEO-IBD) and 15 (32%) of them had monogenic VEO-IBD. Clinical features that differentiated monogenic from nonmonogenic VEO-IBD were neonatal onset, perianal disease, history of consanguinity and sibling death, wasting, stunting, and IBD unclassified phenotype.