Intestinal Stromal Cells in the Turmoil of Inflammation and Defective Connective Tissue Remodeling in Inflammatory Bowel Disease

Drygiannakis, Ioannis MD, PhD
Kolios, George MD, PhD
Filidou, Eirini MSc, PhD
Bamias, Giorgos MD, PhD
Valatas, Vassilis MD, PhD

Gastroenterology Research Laboratory, School of Medicine, University of Crete, Heraklion, Greece
Gastroenterology Clinic, University Hospital of Heraklion, Heraklion, Greece
Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
Gastrointestinal Unit, Third Academic Department of Internal Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece
Gastroenterology Research Laboratory, School of Medicine, University of Crete, Heraklion, Greece
Gastroenterology Clinic, University Hospital of Heraklion, Heraklion, Greece

Address correspondence to: Giorgos Bamias, MD, PhD, Third Academic Department of Internal Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens 11527, Greece ([email protected]).

Received January 16, 2024

Revised April 06, 2024

Online date: April 06, 2024

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Inflammatory Bowel Diseases 30(9):p 1604-1618, September 03, 2024. | DOI: 10.1093/ibd/izae066

Lay Summary

Single-cell sequencing and spatial transcriptomics are now dissecting intestinal stromal cells into multiple phenotypes with distinct roles, in crosstalk with neighboring or infiltrating cells. Pathways involved in disrupted extracellular matrix homeostasis are reviewed to provide relevant pharmacologic targets.