Statin Use with Daptomycin: Do We Finally Have a Definitive Answer?

Watkins, Richard R. MD, MS, FACP, FIDSA, FISAC

Professor of Internal Medicine, Northeast Ohio Medical University, Rootstown, OH

Financial Disclosure: None of the planners of this educational activity have relevant financial relationships to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Infectious Disease Alert 42(4):p 37-38, January 2023.

SYNOPSIS: A meta-analysis on published literature and a disproportionality analysis using Food and Drug Administration data found that statin use was associated with the occurrence of daptomycin-induced musculoskeletal adverse events. In most cases, statin use should be discontinued while patients are on daptomycin.

SOURCE: Chuma M, Nakamoto A, Bando T, et al. Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis. Clin Infect Dis 2022;75:1416-1422.