Systematic Review of In Vitro Studies in Dentistry

How to Conduct It?

Kreve, Simone
Reis, Andréa Cândido dos

¹ Department of Dental Materials and Prosthesis, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, Brazil

Andréa Cândido dos Reis, Department of Dental Materials and Prosthesis, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, Av. Do Café, s/n 14040-904, Ribeirão Preto- State of Sa˜o Paulo 14040-900, Brazil. E-mail: [email protected]

Journal of Advanced Oral Research 16(1):p 17-24, May 2025. | DOI: 10.1177/23202068251318424

Systematic reviews (SRs) are pivotal in synthesizing evidence across primary studies to address specific research questions. In dentistry, particularly in dental materials science, in vitro studies are crucial for evaluating material performance before clinical trials. This article provides a comprehensive guide to conducting SRs focused on in vitro studies, offering step-by-step instructions on formulating research questions, developing search strategies, assessing bias, and synthesizing data. Adherence to PRISMA guidelines is emphasized to ensure transparency and reproducibility. This guide aims to simplify SR processes, fostering the production of high-quality evidence to inform new approaches proposed for clinical use and direct future research.