Clinical Research

Long-Term Functional Patency and Cost-Effectiveness of Arteriovenous Fistula Creation under Regional Anesthesia: a Randomized Controlled Trial

Aitken, Emma^¹
Kearns, Rachel^²
Gaianu, Lucian^³
Jackson, Andrew^¹
Steven, Mark^⁴
Kinsella, John^²
Clancy, Marc^¹
Macfarlane, Alan^²

¹
Department of Renal Surgery, Queen Elizabeth University Hospital, Glasgow, United Kingdom
²
Department of Anaesthesia, Critical Care and Pain Medicine, University of Glasgow, Glasgow, United Kingdom
³
Scottish Health Technologies Group, Healthcare Improvement Scotland, Edinburgh, United Kingdom
⁴
Department of Anaesthesia, Golden Jubilee National Hospital, Clydebank, United Kingdom

Correspondence: Miss Emma Aitken, Department of Renal Surgery, Queen Elizabeth University Hospital, 1345 Govan Road, G51 4TF, Glasgow, United Kingdom. Email: [email protected]

Journal of the American Society of Nephrology 31(8):p 1871-1882, August 2020. | DOI: 10.1681/ASN.2019111209

Significance Statement

Although arteriovenous fistulas (AVFs) are the vascular access modality of choice for patients with established renal failure, high early failure rates limit universal use. Brachial plexus block—regional anesthesia—at the time of AVF creation provides sympathetic blockade and produces venodilation; several studies have demonstrated associated improvement in AVF patency rates. The authors demonstrate for the first time that these perioperative changes translate into sustained improvement in functional patency at 1 year after AVF creation under regional anesthesia compared with local anesthesia. Cost-effectiveness analyses showed that this more labor-intensive technique resulted in net savings. These findings suggest that regional anesthesia has potential to improve AVF usage among the dialysis population, avoid complications of alternative access modalities, reduce surgical workload, and deliver cost savings to healthcare systems at large.

Background

Regional anesthesia improves short-term blood flow through arteriovenous fistulas (AVFs). We previously demonstrated that, compared with local anesthesia, regional anesthesia improves primary AVF patency at 3 months.

Methods

To study the effects of regional versus local anesthesia on longer-term AVF patency, we performed an observer-blinded randomized controlled trial at three university hospitals in Glasgow, United Kingdom. We randomly assigned 126 patients undergoing primary radiocephalic or brachiocephalic AVF creation to receive regional anesthesia (brachial plexus block; 0.5% L-bupivacaine and 1.5% lidocaine with epinephrine) or local anesthesia (0.5% L-bupivacaine and 1% lidocaine). This report includes findings on primary, functional, and secondary patency at 12 months; reinterventions; and additional access procedures (primary outcome measures were previously reported). We analyzed data by intention to treat, and also performed cost-effectiveness analyses.

Results

At 12 months, we found higher primary patency among patients receiving regional versus local anesthesia (50 of 63 [79%] versus 37 of 63 [59%] patients; odds ratio [OR], 2.7; 95% confidence interval [95% CI], 1.6 to 3.8; P=0.02) as well as higher functional patency (43 of 63 [68%] versus 31 of 63 [49%] patients; OR, 2.1; 95% CI, 1.5 to 2.7; P=0.008). In 12 months, 21 revisional procedures, 53 new AVFs, and 50 temporary dialysis catheters were required. Regional anesthesia resulted in net savings of £195.10 (US$237.36) per patient at 1 year, and an incremental cost-effectiveness ratio of approximately £12,900 (US$15,694.20) per quality-adjusted life years over a 5-year time horizon. Results were robust after extensive sensitivity and scenario analyses.

Conclusions

Compared with local anesthesia, regional anesthesia significantly improved both primary and functional AVF patency at 1 year and is cost-effective.

Clinical Trial registry name and registration number

Local Anaesthesia versus Regional Block for Arteriovenous Fistulae, NCT01706354