The complex interplay between mitochondrial dynamics and cardiac metabolism

  • Parra, Valentina
  • Verdejo, Hugo
  • del Campo, Andrea
  • Pennanen, Christian
  • Kuzmicic, Jovan
  • Iglewski, Myriam
  • Hill, Joseph A.
  • Rothermel, Beverly A.
  • Lavandero, Sergio

  • V. Parra · H. Verdejo · A. del Campo · C. Pennanen · J. Kuzmicic · S. Lavandero Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile

    H. Verdejo Departamento Enfermedades Cardiovasculares, Facultad Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

    M. Iglewski · J. A. Hill · B. A. Rothermel · S. Lavandero Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA

    J. A. Hill Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA

    S. Lavandero Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Olivos 1007, Santiago 8380492, Chile e-mail: [email protected]

Published online: 22 January 2011

Journal of Bioenergetics & Biomembranes 43(1):p 47-51, February 25, 2011. | DOI: 10.1007/s10863-011-9332-0

Abstract

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.

Abbreviations: MFN: Mitofusin; OPA1: optic atrophy 1 protein; OMM: outer mitochondrial membrane; IMM: inner mitochondrial membrane; Fis1: mitochondrial fission 1 protein; Drp1: dynamin related protein 1; ΔΨm: mitochondrial membrane potential; OXPHOS: oxidative phosphorylation; CPT1: carnitine palmitoyl transferase 1; PDH: pyruvate dehydrogenase; TCA: tricarboxylic acid cycle
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