Central role of the P2Y₁₂ receptor in platelet activation

Dorsam, Robert T.
Kunapuli, Satya P.

¹Department of Pharmacology,
²Sol Sherry Thrombosis Research Center, and
³Department of Physiology, Temple University Medical School, Philadelphia, Pennsylvania, USA

Address correspondence to: Satya P. Kunapuli, Department of Physiology, Temple University, Room 224, Old Medical School, 3420 N. Broad Street, Philadelphia, Pennsylvania 19140, USA. Phone: (215) 707-4615; Fax: (215) 707-4003; E-mail: [email protected].

Conflict of interest: The authors have declared that no conflict of interest exists.

Nonstandard abbreviations used: proteinase-activated receptor (PAR); 2-methylthio-ADP (2-MeSADP).

Journal of Clinical Investigation 113(3):p 340-345, February 2004.

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y₁₂ receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y₁₂ receptor antagonists that have proven therapeutic value.

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Central role of the P2Y₁₂ receptor in platelet activation