High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases

  • Mueller, Alisa A.
  • Sasaki, Takanori
  • Keegan, Joshua W.
  • Nguyen, Jennifer P.
  • Griffith, Alec
  • Horisberger, Alice M.
  • Licata, Thomas
  • Fieg, Elizabeth
  • Cao, Ye
  • Elahee, Mehreen
  • Marks, Kathryne E.
  • Simmons, Daimon P.
  • Briere, Lauren C.
  • Cobban, Laurel A.
  • Pallais, J. Carl
  • High, Frances A.
  • Walker, Melissa A.
  • Linnoila, Jenny J.
  • Sparks, Jeffrey A.
  • Holers, V. Michael
  • Costenbader, Karen H.
  • Sweetser, David A.
  • Krier, Joel B.
  • Loscalzo, Joseph
  • Lederer, James A.
  • Rao, Deepak A.

  • 1Department of Medicine,

    2Department of Surgery, and

    3Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

    4Center for Genomic Medicine,

    5Department of Pediatrics, and

    6Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

    7Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

    8 The Undiagnosed Diseases Network is detailed in the Supplemental Materials.

Address correspondence to: Deepak Rao, 60 Fenwood Road, Boston, Massachusetts 02115, USA. Email: [email protected].

Authorship note: AAM and TS contributed equally to this work.

Journal of Clinical Investigation 133(24):p e169619, December 15, 2023. | DOI: 10.1172/JCI169619
Copyright © 2023 The American Society for Clinical Investigation, Inc.
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