Don't Get Boxed In: Commentary on the Visual Inspection Practices to Assess Exposure-Response Relationships From Binary Clinical Variables

From Ellicott City, Maryland (Ms Mehrotra); Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland (Dr Florian); and Schools of Pharmacy and Medicine, University of Maryland, Baltimore, Maryland (Dr Gobburu). Submitted for publication July 26, 2011; revised version accepted September 6, 2011. Address for correspondence: Jogarao Gobburu, 20 Penn Street HSF II, Baltimore, MD 21201; e-mail: JGobburu®rx.umaryland.edu.