Repetitive Dosing of Intravenous Levosimendan Improves Pulmonary Hemodynamics in Patients With Pulmonary Hypertension

Results of a Pilot Study

  • Kleber, Franz X. MD, FESC
  • Bollmann, Tom MD
  • Borst, Mathias M. MD
  • Costard-Jäckle, Angelika MD
  • Ewert, Ralf MD
  • Kivikko, Matti MD
  • Petterson, Tiina PhD
  • Pohjanjousi, Pasi MSc
  • Sonntag, Steffen MD
  • Wikström, Gerhard MD, FESC

  • From the ukb, Academic Teaching Hospital, Charité Medical School, Berlin, Germany (Dr Kleber, Dr Sonntag); Christian-Albrechts-Universität, Klinik für Herz- und Gefäßchirurgie, Kiel, Germany (Dr Costard-Jäckle); Universitätsklinikum Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany (Dr Borst); Akademiska hospital, OTM division, Kardiologi, Uppsala, Sweden (Dr Wikström); Ernst-Moritz-Arndt-Universität, Zentrum für Innere Medizin, Greifswald, Germany (Dr Bollmann, Dr Ewert); and Orion Corporation, Orion Pharma, Espoo, Finland (Dr Petterson, Dr Pohjanjousi, Dr Kivikko). Submitted for publication March 12, 2008; revised version accepted August 16, 2008.

Address for correspondence: Franz X. Kleber, MD, FESC, ukb, Academic Teaching Hospital, Charité Medical School, Warener Str 7, 12683 Berlin, Germany.

The Journal of Clinical Pharmacology 49(1):p 109-115, January 2009.
Copyright © 2009 American College of Clinical Pharmacology