The In Vitro Platelet Toxicity Assay (iPTA): A Novel Approach for Assessment of Drug Hypersensitivity Syndrome

From the Ivey Chair in Molecular Toxicology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Mr Elzagallaai, Dr Koren); Department of Medicine, University of Western Ontario, London, Ontario, Canada (Mr Elzagallaai, Dr Koren); Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada (Mr Elzagallaai, Dr Rieder, Dr Koren); Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Dr Rieder); and the CIHR-GSK Chair in Pediatric Clinica Pharmacology,University of Western Ontario, London, Ontario,Canada (Dr Rieder). Submitted for publication October 18, 2009; revised version accepted February 9, 2010. Address for correspondence: Gideon Koren MD, FRCPC, FACMT, Ivey Chair in Molecular Toxicology, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1; e-mail: [email protected].