scRNA-seq profiling of human granulocytes reveals expansion of developmentally flexible neutrophil precursors with mixed neutrophil and eosinophil properties in asthma

Haruna, Nana-Fatima
Politanska, Yuliya
Connelly, Andrew R
O’Connor, Kathrine
Bhattacharya, Sourav
Miklaszewski, Grace E
Pérez-Leonor, Xóchitl G
Rerko, Geddy
Hentenaar, Ian T
Nguyen, Doan C
Lamothe Molina, Pedro Alberto
Bochner, Bruce S
Abdala-Valencia, Hiam
Gill, Michelle A
Lee, F Eun-Hyung
Berdnikovs, Sergejs

Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, 240 East Huron, McGaw M-316, Chicago, IL 60611, United States
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 303 East Superior, Simpson Querrey Biomedical Research Center 5-407, Chicago, IL 60611, United States
Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, 240 East Huron, McGaw M-316, Chicago, IL 60611, United States
Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine in St. Louis, 1 Childrens Place, St. Louis, MO 63110, United States
Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine in St. Louis, 1 Childrens Place, St. Louis, MO 63110, United States
Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, 240 East Huron, McGaw M-316, Chicago, IL 60611, United States
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 303 East Superior, Simpson Querrey Biomedical Research Center 5-407, Chicago, IL 60611, United States
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 303 East Superior, Simpson Querrey Biomedical Research Center 5-407, Chicago, IL 60611, United States
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, 615 Michael Street, Suite 205, Atlanta, GA 30322, United States
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, 615 Michael Street, Suite 205, Atlanta, GA 30322, United States
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, 615 Michael Street, Suite 205, Atlanta, GA 30322, United States
Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, 240 East Huron, McGaw M-316, Chicago, IL 60611, United States
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 303 East Superior, Simpson Querrey Biomedical Research Center 5-407, Chicago, IL 60611, United States
Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine in St. Louis, 1 Childrens Place, St. Louis, MO 63110, United States
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, 615 Michael Street, Suite 205, Atlanta, GA 30322, United States
Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, 240 East Huron, McGaw M-316, Chicago, IL 60611, United States

Corresponding author: Allergy and Immunology/MED, 240 East Huron Street, M-316, Chicago, IL 60611, United States. Email: [email protected]

Conflict of interest statement. None declared.

Received November 22, 2023

Received in revised form April 03, 2024

Accepted May 01, 2024

Revised July 08, 2024

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Journal of Leukocyte Biology 116(5):p 1184-1197, November 2024. | DOI: 10.1093/jleuko/qiae120