Differences in tumor-associated T-cell receptor repertoires between early-onset and average-onset colorectal cancer

Tsai, Ya-Yu PhD, MS; Conceptualization; Data curation; Formal analysis; Investigation; Validation; Writing - original draft; Writing - review & editing
Nair, Kanika G MD; Data curation; Project administration
Barot, Shimoli V MD; Data curation; Project administration
Xiang, Shao MD; Data curation; Project administration
Kamath, Suneel MD; Data curation; Project administration; Writing - review & editing
Melas, Marilena PhD; Data curation
Walker, Christopher P BS; Data curation; Project administration
Srivastava, Raghvendra M PhD; Data curation
Osborne, Nicole BS; Data curation
Chan, Timothy A MD, PhD; Conceptualization; Resources; Supervision
Mitchem, Jonathan B MD; Conceptualization; Writing - review & editing
Bonner, Joseph D PhD; Data curation; Formal analysis
McDonnell, Kevin J MD, PhD; Project administration
Idos, Gregory E MD, MS; Project administration
Sanz-Pamplona, Rebeca PhD; Data curation; Formal analysis; Writing - review & editing
Greenson, Joel K MD; Data curation; Project administration; Resources
Rennert, Hedy S MPH; Data curation; Project administration; Resources; Supervision; Validation
Rennert, Gad MD, PhD; Data curation; Funding acquisition; Methodology; Project administration; Resources; Supervision; Validation
Moreno, Victor PhD; Data curation; Formal analysis; Funding acquisition; Methodology; Project administration; Resources; Supervision; Validation; Writing - review & editing
Gruber, Stephen B MD, PhD; Conceptualization; Data curation; Funding acquisition; Investigation; Methodology; Project administration; Resources; Supervision; Validation; Writing - review & editing
Khorana, Alok A MD; Conceptualization; Data curation; Resources; Supervision; Writing - review & editing
Liska, David MD; Conceptualization; Data curation; Funding acquisition; Resources; Supervision
Schmit, Stephanie L PhD, MPH; Conceptualization; Data curation; Formal analysis; Funding acquisition; Investigation; Project administration; Resources; Supervision; Writing - original draft; Writing - review & editing

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Cleveland Clinic Center for Young-Onset Colorectal Cancer, Cleveland Clinic, Cleveland, OH, USA
Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA
Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA
Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA
Cleveland Clinic Center for Young-Onset Colorectal Cancer, Cleveland Clinic, Cleveland, OH, USA
Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA
Case Comprehensive Cancer Center, Cleveland, OH, USA
Cleveland Clinic Lerner College of Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Department of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA
Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA
Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA
Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA
VA Northeast Ohio Health System, Cleveland, OH, USA
Department of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
Department of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
Department of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Barcelona, Spain
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain
Hospital Universitario Lozano Blesa, Aragon Health Research Institute (IISA), ARAID Foundation, Aragon Government, Zaragoza, Spain
University of Michigan, Ann Arbor, MI, USA
B. Rappaport Faculty of Medicine, Technion and the Association for Promotion of Research in Precision Medicine (APRPM), Haifa, Israel
B. Rappaport Faculty of Medicine, Technion and the Association for Promotion of Research in Precision Medicine (APRPM), Haifa, Israel
Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Barcelona, Spain
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain
Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona, Barcelona, Spain
Department of Medical Oncology and Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
Cleveland Clinic Center for Young-Onset Colorectal Cancer, Cleveland Clinic, Cleveland, OH, USA
Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH, USA
Cleveland Clinic Lerner College of Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
Cleveland Clinic Center for Young-Onset Colorectal Cancer, Cleveland Clinic, Cleveland, OH, USA
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Cleveland Clinic Center for Young-Onset Colorectal Cancer, Cleveland Clinic, Cleveland, OH, USA
Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, OH, USA

Correspondence to: Stephanie L. Schmit, PhD, MPH, Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA (e-mail: [email protected]).

Received January 24, 2024

Received in revised form May 1, 2024

Accepted June 13, 2024

Revised July 14, 2024

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Journal of the National Cancer Institute 116(10):p 1645-1653, October 2024. | DOI: 10.1093/jnci/djae143