Reduced Magnitude and Durability of Humoral Immune Responses to COVID-19 mRNA Vaccines Among Older Adults

Brockman, Mark A
Mwimanzi, Francis
Lapointe, Hope R
Sang, Yurou
Agafitei, Olga
Cheung, Peter K
Ennis, Siobhan
Ng, Kurtis
Basra, Simran
Lim, Li Yi
Yaseen, Fatima
Young, Landon
Umviligihozo, Gisele
Omondi, F Harrison
Kalikawe, Rebecca
Burns, Laura
Brumme, Chanson J
Leung, Victor
Montaner, Julio S G
Holmes, Daniel
DeMarco, Mari L
Simons, Janet
Pantophlet, Ralph
Niikura, Masahiro
Romney, Marc G
Brumme, Zabrina L

Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada
Department of Chemistry, Simon Fraser University, Burnaby, Canada
Division of Medical Microbiology and Virology, St Paul’s Hospital, Vancouver, Canada
Department of Medicine, University of British Columbia, Vancouver, Canada
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada

M. A. B., M. G. R., and Z. L. B. contributed equally.

Correspondence: Mark A. Brockman, PhD, Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada ([email protected]).

Received September 09, 2021

Accepted December 07, 2021

Revised January 29, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Journal of Infectious Diseases 225(7):p 1129-1140, April 01, 2022. | DOI: 10.1093/infdis/jiab592