Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure

Akdag, Ibrahim
Ersoy, Alpaslan
Kahvecioglu, Serdar
Gullulu, Mustafa
Dilek, Kamil

Departments of Nephrology and Rheumatology, Uludagğ University Medical School, Bursa - Turkey

Address for correspondence:

Ibrahim Akdag, M.D.

Department of Nephrology

Uludagğ University Medical School

16059 Gorukle

Bursa, Turkey

[email protected]

Received: August 23, 2005 Revised: June 22, 2006 Accepted: July 17, 2006

Journal of Nephrology 19(4):p 515-517, July 2006.

ABSTRACT:

Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxication occurring with the administration of clarithromycin.